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BACKGROUND The present study was designed to define the prevalence and characteristics of skeletal muscle alterations in patients with chronic heart failure (CHF) and their relation to exercise capacity. METHODS AND RESULTS The ultrastructure of skeletal muscle was analyzed by ultrastructural morphometry in 57 patients with CHF and 18 healthy controls.(More)
OBJECTIVES The expression and localization of inducible nitric oxide (NO) synthase (NOS II) was evaluated as a source of NO which has been shown to affect muscle contraction. BACKGROUND Advanced stages of chronic heart failure are associated with systemic activation of cytokines which have been shown to stimulate the expression of NOS II in various cell(More)
The cells of the connective tissues contain lysosomes with enzymes capable of degrading intercellular substances (collagen, elastin, proteoglycans) and release their enzymes in membrane-bound or in free form into their intercellular substance. In this way extracellularly located lysosomes (= matrix lysosomes) can be detected by morphological and enzymatic(More)
BACKGROUND After myocardial infarction, the noninfarcted left ventricle develops reactive hypertrophy associated with a depressed coronary flow reserve, myocardial interstitial fibrosis, and reduced capillary density. The present study investigated the comparative cardiac effects of chronic angiotensin-converting enzyme (ACE) inhibition and selective(More)
Cartilage tissue from four different areas of the articular surface of the talar trochlea was analysed by light microscopic morphometry in the case of a juvenile collective (7 years of age), an adult one (30 years of age) and a senile one (80 years of age). The following observations were impressive: 1. With the exception of the cytoplasm fraction in the(More)
Patients with immunodeficiency or treatment-related immunosuppression are at an increased risk of developing severe herpes simplex virus (HSV) infection. We present a fatal case of a generalized HSV-1 infection in a 22-year-old female afflicted by acute lymphoblastic leukemia who was treated with polychemotherapy. The terminal clinical course was(More)
The Dieulafoy lesion is a rare cause of severe upper gastrointestinal bleeding associated with a significant mortality. Rebleeding from undiscovered lesions is frequent and often fatal. The outcome depends on a high degree of suspicion for the condition. In any age group, the entity may be underdiagnosed rather than truly rare. It is particularly uncommon(More)
The role of the tumour-suppressor gene p53 in the tumorigenesis of head and neck cancer has been well established, but the clinical significance of p53 alteration is still unclear. A group of 50 patients with head and neck squamous cell carcinoma (HNSCC) were investigated for p53 alterations. DNA was extracted from fresh tumour samples and polymerase chain(More)
The age dependent profile changes and the predilection areas of arthrosis in ankle joints were investigated using a series of patients with foregoing accidental trauma (316 cases) and from 306 consecutive autopsy cases. Biometrical analysis was carried out by measuring the profile of talar trochlea in sagittal and frontal plane as well as the relative area(More)
We report a case of Wegener's granulomatosis (WG) which differed significantly from the WHO-definition. The patient presented himself with fever and skin lesions which exacerbated after penicillin therapy. The nasal biopsy did not reveal the expected classical vasculitis and granulomas, which were present at autopsy only in the liver and spleen. We(More)