Ursula Götz

Learn More
Recently, the inhibition of epithelial-mesenchymal-transition (EMT) by p53 has been described as a new mode of tumor suppression which presumably prevents metastasis. Here we report that activation of p53 down-regulates the EMT-inducing transcription factor SNAIL via induction of the miR-34a/b/c genes. Suppression of miR-34a/b/c caused up-regulation of(More)
Analytical ultracentrifugation at different sets of conditions in the temperature range between 10 and 34° C shows that mixtures of l-noradrenaline and adenosine-5′-triphosphate in the presence of Ca2+ always sediment jointly, i.e. with only one single schlieren peak together with intragranular expanded proteins obtained from bovine adrenal medulla. In(More)
Embryonic cells transiently express an embryonic muscarinic system during morphogenesis. Stimulation of the embryonic muscarinic receptor results in biphasic intracellular Ca2+ mobilization: an initial "peak" due to Ca2+ release from intracellular stores is followed by a sustained "plateau" of enhanced cytoplasmic Ca2+ due to influx of extracellular Ca2+.(More)
Bilateral orchiectomy, performed 1 week before initiation of weekly sc injections of N-nitrosobis(2-oxopropyl)amine (BOP), prevented induction of hyperplastic and neoplastic lesions in the nasal and paranasal cavities of outbred Wistar-derived MRC rats. However, in BOP-treated rats without surgery or with bilateral vesiculectomy, the incidences of these(More)
We have previously identified the long non-coding RNA LINC01021 as a direct p53 target (Hünten et al. Mol Cell Proteomics. 2015; 14:2609-2629). Here, we show that LINC01021 is up-regulated in colorectal cancer (CRC) cell lines upon various p53-activating treatments. The LINC01021 promoter and the p53 binding site lie within a MER61C LTR, which originated(More)
Utilizing (3H) cyclosporin C (3H CS-C), a dihydroderivative of cyclosporin A (CS-A), an assay for cyclosporin receptors on human peripheral blood lymphocytes was developed. The specific binding of (3H) CS-C was saturable, time-dependent, and reversible. A Kd of 1.2 x 10(-7) M and a maximum binding capacity (Bmax) of 7 pmol/10(6) cells was calculated from(More)
Age-dependency of beta-Lipoproteins as Compared to Cholesterol and Triglycerides in the Serum of SPF Rats Total cholesterol and triglyceride values increase with age in rats (male greater than female). Correlated to these lipid increases, an increase of serum turbidity and of total beta-lipoproteins (pre-beta- and beta) can also be observed. The results of(More)
The role of protein in pancreatic carcinogenesis was examined in outbred Syrian golden hamsters treated with the pancreatic carcinogen N-nitrosobis(2-oxopropyl)amine (BOP) and fed a purified protein-free diet (PPFD). The PPFD was fed for 28 days from 8 weeks of age; before and after animals were fed PPFD, they were given a commercial diet (CD). BOP was(More)
Specific binding of [3H]-cyclosporin C (3H-CS-C), an immunosuppressive oligopeptide, was characterized on different mouse lymphocytes. The binding was saturable, time-dependent and reversible; and KD of 1.5 x 10(-7) M and maximum binding capacity Bmax of 35 pmol/4 x 10(6) cells was found for thymocytes. A computerized analysis of the data confirmed a single(More)
  • 1