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A prospective clinical trial was conducted to determine the skeletal and dental contributions to the correction of overjet and overbite in Class III patients. Thirty patients (12 males and 18 females with a mean age of 8.4 +/- 1.7 years) were treated consecutively with protraction headgear and fixed maxillary expansion appliances. For each patient, a(More)
Cephalometric landmark validity (the difference between the estimated landmark and the true landmark) has surprisingly not previously been comprehensively evaluated, and no previous study has examined the validity of cephalometric angles and distances. The aim of this study was to investigate the validity of 15 commonly used skeletal and dental(More)
PTHrP is a key factor regulating the pace of endochondral ossification during skeletal development. Mandibular advancement solicits a cascade of molecular responses in condylar cartilage. However, the pace of cellular maturation and its effects on condylar growth are still unknown. The purpose of this study was to evaluate the pattern of expression of PTHrP(More)
The effects of the progressive activation of the Herbst appliance on the activity of the masseter and temporalis elevator muscles of the mandible were monitored in a group of 14 consecutively treated 10-15-year-old subjects with an Angle Class II, division I malocclusion. A cast silver splint Herbst appliance was activated in multiple stages at a rate of 2(More)
Indian hedgehog (Ihh) is a critical mediator transducing mechanical signals to stimulate chondrocyte proliferation. To clarify the cellular signal transduction pathway that senses and converts mechanical signals into tissue growth in mandibular condyle, we evaluated Ihh expression and its relation to the kinetics of replicating mesenchymal cells in condylar(More)
The definitions of cephalometric landmarks include relative terms that are dependent on the orientation of the head (e.g., lowest, most posterior) and head orientation differ widely during cephalometry (e.g., Frankfort plane horizontal, natural head posture). The purpose of this study was to quantify the effect of head posture changes on the commonly used(More)
The aim of this study was to investigate the space closure and occlusal changes in 11 subjects (mean age 11.8 years) with normal occlusion and agenesis of the mandibular second premolar, after extraction of the mandibular secondary primary molar and the maxillary second premolar on the side of the agenesis. The treatment started when the first premolars(More)
The aims of this investigation were to identify the temporal expression of vascular endothelial growth factor (VEGF) in the mandibular condyle and to correlate it with the pattern of new bone formation during stepwise mandibular advancement. Two hundred and fifty female, 35-day-old Sprague-Dawley rats were randomly divided into 10 groups, with 10 rats(More)
Few previous cephalometric studies have used dry skulls in order to eliminate the effects of the facial soft tissues. The aim of this study were to quantify the intra-examiner reproducibility of the commonly used cephalometric landmarks, angles and distances, using dry skulls and to compare these errors with previous error data obtained from normal(More)
The objective of this study was to assess the feasibility of virtual models as an alternative to orthodontic plaster models. Virtual dental models (obtained from OrthoCAD) and corresponding plaster models of 80 patients in the permanent dentition were randomly selected from patients seeking orthodontic care. Inter-examiner error was assessed by measuring(More)