Una Buckley

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Autonomic regulation therapy (ART) is a rapidly emerging therapy in the management of congestive heart failure secondary to systolic dysfunction. Modulation of the cardiac neuronal hierarchy can be achieved with bioelectronics modulation of the spinal cord, cervical vagus, baroreceptor, or renal nerve ablation. This review will discuss relevant preclinical(More)
OBJECTIVES The aims of this study were to examine human renal arteries and to accurately characterize their sympathetic innervation and location using CD-56 immunohistochemistry stains to highlight Neural Cell Adhesion Molecules (N-CAM). BACKGROUND Porcine models have often formed the basis for design of denervation technology, with only a limited number(More)
BACKGROUND Patients' awareness of the increased cardiovascular risk associated with their diabetes is poorly documented. AIM The aim of this study was to assess the awareness of diabetes complications among patients with diabetes in Ireland. METHODS Patients attending diabetes outpatient clinics in two teaching hospitals in different regions of the(More)
BACKGROUND Selective bilateral cervicothoracic sympathectomy has proven to be effective for managing ventricular arrhythmias in the setting of structural heart disease. In the procedure currently used, the caudal portions of both stellate ganglia along with thoracic chain ganglia down to T4 ganglia are removed. OBJECTIVE The purpose of this study was to(More)
BACKGROUND Neuromodulation of the paravertebral ganglia by using symmetric voltage controlled kilohertz frequency alternating current (KHFAC) has the potential to be a reversible alternative to surgical intervention in patients with refractory ventricular arrhythmias. KHFAC creates scalable focal inhibition of action potential conduction. OBJECTIVE The(More)
BACKGROUND Autonomic dysfunction contributes to induction of ventricular tachyarrhythmia (VT). OBJECTIVE To determine the efficacy of charge-balanced direct current (CBDC), applied to the T1-T2 segment of the paravertebral sympathetic chain, on VT inducibility post-myocardial infarction (MI). METHODS In a porcine model, CBDC was applied in acute animals(More)
BACKGROUND Anaemia is an increasingly recognised entity in patients with diabetes mellitus. AIMS We aimed to determine the prevalence of anaemia in our population of patients with diabetes, and to examine the factors associated with anaemia. METHODS The haemoglobin (Hb) levels in a consecutive series of patients attending for annual review of their(More)
Modern replica plane reflection gratings are now easily and cheaply available. These enable high-precision optical spectroscopy to be carried out in the undergraduate teaching laboratory. We illustrate this by describing experimental measurements (i) on the separation of the sodium doublets and (ii) on the ratio of the mass of the proton to the mass of the(More)