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Autonomic regulation therapy (ART) is a rapidly emerging therapy in the management of congestive heart failure secondary to systolic dysfunction. Modulation of the cardiac neuronal hierarchy can be achieved with bioelectronics modulation of the spinal cord, cervical vagus, baroreceptor, or renal nerve ablation. This review will discuss relevant preclinical(More)
OBJECTIVES The aims of this study were to examine human renal arteries and to accurately characterize their sympathetic innervation and location using CD-56 immunohistochemistry stains to highlight Neural Cell Adhesion Molecules (N-CAM). BACKGROUND Porcine models have often formed the basis for design of denervation technology, with only a limited number(More)
BACKGROUND Anaemia is an increasingly recognised entity in patients with diabetes mellitus. AIMS We aimed to determine the prevalence of anaemia in our population of patients with diabetes, and to examine the factors associated with anaemia. METHODS The haemoglobin (Hb) levels in a consecutive series of patients attending for annual review of their(More)
BACKGROUND Patients' awareness of the increased cardiovascular risk associated with their diabetes is poorly documented. AIM The aim of this study was to assess the awareness of diabetes complications among patients with diabetes in Ireland. METHODS Patients attending diabetes outpatient clinics in two teaching hospitals in different regions of the(More)
BACKGROUND Selective bilateral cervicothoracic sympathectomy has proven to be effective for managing ventricular arrhythmias in the setting of structural heart disease. In the procedure currently used, the caudal portions of both stellate ganglia along with thoracic chain ganglia down to T4 ganglia are removed. OBJECTIVE The purpose of this study was to(More)
Modern replica plane reflection gratings are now easily and cheaply available. These enable high-precision optical spectroscopy to be carried out in the undergraduate teaching laboratory. We illustrate this by describing experimental measurements (i) on the separation of the sodium doublets and (ii) on the ratio of the mass of the proton to the mass of the(More)
BACKGROUND Imbalances in the autonomic nervous system, namely, excessive sympathoexcitation, contribute to ventricular tachyarrhythmias. While thoracic epidural anesthesia clinically suppresses ventricular tachyarrhythmias, its effects on global and regional ventricular electrophysiology and electrical wave stability have not been fully characterized. The(More)
This editorial refers to 'The effect of duration of follow-up and presence of competing risk on lifespan-gain from implantable cardioverter defibrillator therapy: who benefits the most?' † , by C. Raphael et al., on page 1676. In certain parts of the world, cardiologists struggle on a daily basis to convince government-run health services to allow them to(More)