Umarkhon Azizov

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i. V. G. Kitaeva, N. M. Voronina, N. I. Latosh, at al., in: Organic Synthesis and Biological Activity [in Russian], Sverdlovsk (1978), p. 42. 2. V. G. Kitaeva, R. I. Ishmetova, I. I. Latosh, et el., in: Chemical Means of Plant Protection [in Russian], Ufa (1982), p. 35. 3. V. G. Kitaeva, R. Io Ishmetova, N. I. Latosh, and N. M. Voronina, Khim. Geterotsikl.(More)
Arctium lappa L. (Compositae) (burdock) is a large perennial herbaceous plant that has been known since antiquity for its useful properties [1]. Roots of burdock are used in folk medicine as a tincture, decoction, extract, and oil for gout, rheumatism, and several skin diseases and as a diuretic and pathogenic agent. It is used topically for eczema, ulcers,(More)
In continuation of our previous work devoted to the search for antiinflammatory agents among the derivatives of arylketocarboxylic acids [1 – 3], we have synthesized a series of new derivatives belonging to aromatic -ketocarboxylic acids and studied their antiinflammatory activity. The group of new compounds includes phenylhydrazone (I), thiosemicarbazone(More)
i. R. A. Kuroyan, S. A. Pogosyan, and N. P. Grigoryan, Arm. Khim. Zh., 4_~4, No. 3, 166 (1991). 2. M. D. Mashkovskii, I. !. Andreeva, and A. I. Polezhaeva, Pharmacology of Antidepressants [in Russian], Moscow (1983). 3. R. E. Safpazbekyan and R. S. Sukasyan, Biol. Zh. Arm., 22, No. I0, 43-49 (1969). 4. A. A. Chachovan and B. T. Garibdzhanyan, Biol. Zh.(More)
1.1 Oxidation of IV with Chromium Compounds. At present the most widely accepted method for the preparation of I is oxidation of IV with chromic acid in a solution of acetic acid or sulfuric acid. The method is used for the production of vitamin K 3. The yield of I is 38-42%; in the presence of a crown ether the yield of the product can be raised to 62%.(More)
Yu. A. Bogdarin, G. A. Boyarinov, N. S. Nikolenko, et al., Khim.-farm. Zh.,No. 4, 9597 (1980). A. A. Lur'e, Chromatographic Materials [in Russian], Moscow (1978). N. P. Maksyugina, F. E. Kagan, L. A. Kirichenko, et al., Methods of Analysis of Drugs [in Russian], Kiev (1984). G. T. Pis'ko, Vrach. Delo., No. 3, 4-9 (1977). V. A. Supina, Packed Columns in Gas(More)
Experiments on various animals showed that fensulkal, a new phenylglyoxylic acid derivative, possesses a high antiinflammatory activity and low toxicity, markedly exceeding butadion in the therapeutic index. The mechanism of the antiphlogistic effect of fensulkal is due to its antagonism with respect to mediators of the inflammatory process and the ability(More)
In the title compound, C(14)H(16)N(6)O(6)·C(2)H(6)O·H(2)O, both substit-uents of the benzene ring are approximately planar with maximum deviations from the mean plane of 0.0561 (12) (an imine N atom) and 0.1419 (11) Å (a meth-oxy O atom). The substituents are tilted out of the plane of the benzene ring by 64.48 (4) and 70.08 (5)°, respectively. In the(More)
In addition to the antiinflammatory activity, the overall action and acute toxicity were studied for the following compounds: phenylglyoxylic acid (PGA) potassium salt C6H sCOCOOK (I), PGA propargyl ester C~H~COCOOCH2C~CH (II), PGA ~-bromopropargyl ester C6H 5COCOOCH2C~CBr (III), PGA ~-iodopropargyl ester C6HsCOCOOCH2~CI (IV), p-nitrophenyLglyoxylic acid(More)