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Prediction of Structure of Human WNT-CRD (FZD) Complex for Computational Drug Repurposing
TLDR
The dimeric cysteine-rich domain was found to fit into the evolutionarily conserved U-shaped groove of WNT protein, thus providing a strong hydrophobic moiety for the frizzled receptor and serving as the largest binding pocket for WNT-FZD interaction.
Exploration of databases and methods supporting drug repurposing: a comprehensive survey
TLDR
A survey of 102 of the most promising and drug-relevant databases reported to date is provided and several examples of how multi-database exploration can facilitate drug repurposing are provided.
Silver, titanium dioxide, and zinc oxide nanoparticles trigger miRNA/isomiR expression changes in THP-1 cells that are proportional to their health hazard potential
TLDR
This study integrated gene and miRNA expression profiles from the same cells to propose miRNA biomarkers of adverse exposure to metal-based nanoparticles, and identified a co-regulated miR-mRNA cluster predicted to be highly relevant for cellular response to metal ion homeostasis.
Integrative analyses of conserved WNT clusters and their co-operative behaviour in human breast cancer
TLDR
It is proposed that SOX9 and TCF4 may compete for binding at the promoters of WNT family genes thus regulating the disease phenotype and therefore regulating the transcriptional regulation.
Minimal information for Chemosensitivity assays (MICHA): A next-generation pipeline to enable the FAIRification of drug screening experiments
TLDR
The launching of MICHA (Minimal Information for Chemosensitivity Assays), which provides an integrative web server and database to obtain compound annotation including chemical structures, targets, and disease indications, and a wider adoption of a community-driven effort to improve the open access of drug sensitivity assays is envisaged.
Minimal information for chemosensitivity assays (MICHA): a next-generation pipeline to enable the FAIRification of drug screening experiments
TLDR
The launching of Minimal Information for Chemosensitivity Assays (MICHA), which provides an integrative web server and database to obtain compound annotation including chemical structures, targets and disease indications, and envisage a wider adoption of a community-driven effort to improve the open access of drug sensitivity assays.