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BACKGROUND Ascitic fluid infection (AFI) in cirrhotic patients has a high morbidity and mortality. It has two variants namely, spontaneous bacterial peritonitis (SBP) and culture negative neutrocytic ascites (CNNA). The aim of this study was to determine the outcome in cirrhotic patients with culture positive (SBP) and culture negative neutrocytic ascites.(More)
OBJECTIVE To determine precipitants of hepatic encephalopathy (HE) and their impact on hospital stay and mortality. STUDY DESIGN Cross-sectional, analytical study. PLACE AND DURATION OF STUDY The Aga Khan University Hospital, from January 2005 to December 2007. METHODOLOGY Consecutive patients admitted with different grades of HE were evaluated(More)
OBJECTIVES Brain abscess is a serious life-threatening complication of several diseases. The objective of this study was to look at the clinical profile of patients, predisposing conditions, microbiology and outcome of children suffering from brain abscess. METHODS Thirty children aged less than 15 years were reviewed. There were 15 males and 15 females.(More)
OBJECTIVE To observe beneficial effects of somatostatin analogues in terms of time taken by the enterocutaneous fistula to close, total hospital stay, cost of treatment and mortality. DESIGN A comparative study. PLACE AND DURATION OF STUDY The study was carried out from 01-10-1999 to 30-09-2002 in Surgical Units of Bahawal Victoria Hospital, Bahawalpur.(More)
There is a paucity of data on the impact of hepatitis D virus (HDV) in patients with hepatitis B virus (HBV) infection from South Asia. We studied the impact of HDV co-infection on virological and clinical characteristics. We collected data of 480 patients with HBsAg positive and a detectable HBV DNA PCR, who presented to the Aga Khan University, Karachi(More)
INTRODUCTION The aim of this study was to evaluate the spectrum of cardiac involvement and its outcome in beta-thalassaemia major. METHODS There were 75 patients with a mean age of 13.8 (+/- 5.5) years, of whom 33 were male and 42 were female. Clinical history, examination and laboratory investigations were assessed. Electrocardiograms, chest radiographs(More)
OBJECTIVE To determine the frequency and specific characteristic features of portal hypertensive gastropathy (PHG) in cirrhosis due to viral etiology. STUDY DESIGN Cross-sectional descriptive study. PLACE AND DURATION OF STUDY The Aga Khan University Hospital, Karachi, from June 2006 till June 2008. METHODOLOGY Patients with hepatitis B and C(More)
Background. Uric acid can acutely activate various inflammatory transcription factors. Since high levels of oxyradicals and lower antioxidant levels in septic patients are believed to result in multiorgan failure, uric acid levels could be used as a marker of oxidative stress and poor prognosis in patients with sepsis. Design. We conducted a prospective(More)
Upper gastrointestinal (UGI) bleeding secondary to a ruptured splenic artery (SA) pseudoaneurysm into the stomach is a rare but a life-threatening condition. Owing to the low prevalence, it remains a diagnostic and therapeutic challenge. A frail 77-year-old Caucasian female presented with epigastric pain and hematemesis. Endoscopy was non-diagnostic for an(More)
OBJECTIVE To assess the diagnostic accuracy of the Rydel-Seiffer tuning fork versus the qualitative 128-Hz tuning fork for detecting sensory axonal neuropathy. METHODS One hundred consecutive patients seen at the Neurology Outpatient Electromyography clinic at a major academic center were recruited and consented for this study. Study personnel who were(More)