Ulrike Leiss

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BACKGROUND Median survival time of recurrent embryonal brain tumors is short regardless of salvage chemotherapy used. An evolving alternative approach to conventional chemotherapy is to target neovascularization by interfering with tumor angiogenesis at various levels. PROCEDURE From November 2006 to December 2010, 16 patients (median age: 9 years) with(More)
Atypical teratoid rhabdoid tumors (ATRTs) are recently defined highly aggressive embryonal central nervous system tumors with a poor prognosis and no definitive guidelines for treatment. We report on the importance of an initial correct diagnosis and disease-specific therapy on outcome in 22 consecutive patients and propose a new treatment strategy. From(More)
BACKGROUND Tumours of the central nervous system (CNS) are the most frequent solid tumours and the second most frequent type of cancer in children and adolescents. Overall survival has continuously improved in Germany, since an increasing number of patients have been treated according to standardised, multicentre, multimodal treatment recommendations,(More)
Ausgehend von den rechtlichen Grundlagen, die die Teilhabe von Kindern regeln, werden die Gründe für das Auseinanderklaffen zwischen den Empfehlungen zur Partizipation und ihrer Umsetzung im ärztlichen Praxisalltag dargelegt und diskutiert. Unser Überblick über die zahlreichen wissenschaftlichen Untersuchungen der Arzt-Kind-Eltern-Triade zeigt, dass die(More)
Ist bei Kindern und Jugendlichen die Aufmerksamkeit beeinträchtigt, führt dies häufig zu Schwierigkeiten im Alltag, so kann etwa die schulische Integration massiv erschwert sein. Bekannte Störungsbilder sind das Aufmerksamkeitsdefizit-Hyperaktivitäts-Syndrom (ADHS) und Aufmerksamkeitsdefizitsyndrom ohne Hyperaktivität (ADS). Deutlich weniger(More)
http://dx.doi.org/10.1016/j.jpeds.2015.05.040 E P A C hildren’s competence and autonomy develop through direct social personal experience, not only through general developmental age and physical growth. Some of the youngest children can be among the most informed and confident patients if adequately informed. The competence of children depends on the(More)
Over the past decades, many studies used global outcome measures like the IQ when reporting cognitive outcome of pediatric brain tumor patients, assuming that intelligence is a singular and homogeneous construct. In contrast, especially in clinical neuropsychology, the assessment and interpretation of distinct neurocognitive domains emerged as standard. By(More)
INTRODUCTION Considering that parental well-being influences the healing process of a child significantly, the relevance of psychosocial care of parents with children with cancer is obvious. Since the parental distress has hardly been studied in Germany, this study examines the burdens of parents of children with cancer. In addition, it provides a(More)
Given the increased survival rates in patients with pediatric central nervous system tumors, late effects such as treatment- and/or illness-related neurologic sequelae as well as neuropsychological deficits and social difficulties have moved into focus in follow-up care. In order to provide personalized treatment recommendations for pediatric brain tumor(More)