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CONTEXT Major depressive disorder (MDD) is characterized by diverse metabolic and functional abnormalities that occur in, among other regions, the pregenual anterior cingulate cortex (pgACC), a cortical region linked to anhedonia. OBJECTIVES To contextualize metabolic, functional, and clinical parameters and thus to reveal cellular mechanisms related to(More)
Schizophrenia is a major psychiatric disease, which affects the centre of the personality, with severe problems of perception, cognition as well as affective and social behaviour. In cerebrospinal fluid of drug-free schizophrenic patients, a significant decrease in the level of total glutathione (GSH) by 27% (P<0.05) was observed as compared to controls, in(More)
Migraine pathophysiology possibly involves deficient mitochondrial energy reserve and diminished cortical habituation. Using functional magnetic resonance spectroscopic imaging (fMRSI), we studied cortical lactate changes during prolonged visual stimulation to search for different pathophysiological mechanisms in clinically distinct subgroups of migraine(More)
The human anterior cingulate cortex (ACC) is part of the default-mode network that shows predominant negative blood oxygen level-dependent (BOLD) responses in functional magnetic resonance imaging (fMRI). We combined fMRI during emotional processing and resting-state magnetic resonance spectroscopy measurements and observed that the concentration of GABA in(More)
A large body of published work shows that proton (hydrogen 1 [(1)H]) magnetic resonance (MR) spectroscopy has evolved from a research tool into a clinical neuroimaging modality. Herein, the authors present a summary of brain disorders in which MR spectroscopy has an impact on patient management, together with a critical consideration of common data(More)
In clinical MR spectroscopy at higher field strengths, lactate may show reduced or absent signal intensity at an echo time of 144 ms. Although this false-negative result may be predicted from theory, experimental verification and clinical impact have not been fully established. Using scanners from 3 major vendors, spectra from phantoms and patients(More)
Two-dimensional (2D) strong-coupling point-resolved spectroscopy (S-PRESS) is introduced as a novel approach to (1)H MR spectroscopy (MRS) in the prostate. The technique provides full spectral information and allows for an accurate characterization of the citrate (Cit) signal. The method is based on acquiring a series of PRESS spectra with constant total(More)
Quantitative magnetic resonance spectroscopy (MRS) amends differential diagnostics of neurological pathology. However, due to technical challenges, it has rarely been applied to the spinal cord and has mainly been restricted to the very upper part of the cervical spine. In this work, an improved acquisition protocol is proposed that takes technical problems(More)
This work summarizes and puts in an overall perspective studies done within CMS concerning the discovery potential for squarks and gluinos, sleptons, charginos and neutralinos, SUSY dark matter, lightest Higgs, sparticle mass determination methods and the detector design optimisation in view of SUSY searches. It represents the status of our understanding of(More)
Manganese (Mn) is a well established neurotoxin associated with specific damage to the basal ganglia in humans. The phenotype associated with Mn neurotoxicity was first described in two workers with occupational exposure to Mn oxide (Couper, 1837). Although the description did not use modern clinical terminology, a parkinsonian illness characterized by(More)