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Characterization of SPINK9, a KLK5-specific inhibitor expressed in palmo-plantar epidermis
- K. Brännström, Anders Öhman, Ulrich von Pawel Rammingen, A. Olofsson, M. Brattsand
- Biology, Medicine
- Biological chemistry
- 1 May 2012
Modeling of the enzyme-inhibitor complexes showed that the reactive loop of SPINK9 fits very well into the deep negatively charged binding pocket of KLK5 and substitution with a positively charged amino acid at position 48 resulted in a more efficient inhibitor at higher pH. Expand