Learn More
Male Wistar rats received for 4 weeks a linoleic acid (LA) rich (13.3 cal. % LA) or an LA deficient (0.5 cal. % LA) diet as well as 1.5% sodium chloride as drinking fluid. Compared with the LA rich diet the LA deficient diet caused an increase in blood pressure of about 10 mmHg. Indomethacin treatment (2 X 1 mg/kg/day s.c.) increased the blood pressure in(More)
All vasodilatory drugs reported in this chapter possess an antiaggregatory effect on platelets, some of them with a synergistic effect on prostacyclin-induced inhibition of aggregation. Thus, the question seems valid whether the antiaggregatory effect represents one part of their antianginal and antihypertensive action. Some vasodilators stimulate the(More)
1 The influence of prostacyclin (PGI2) on the release of adenosine in rabbit hearts perfused by the Langendorff method was examined under normal conditions of perfusion and during perfusion with the adenosine antagonist, aminophylline. 2 PGI2 increased both coronary flow and the myocardial release of adenosine in a dose-dependent manner. Aminophylline at a(More)
For testing antiaggregatory activity of substances in vivo we used transient decrease of circulating platelet number in rabbit blood after rapid i. v. injection of arachidonic acid (AA) as sign of increased thrombocyte aggregates within the tissues. We tested aspirin, molsidomine, trapidil, and 6 trapidil derivatives. Antiaggregatory effects of aspirin,(More)
Nitroglycerin (NG) did not influence the synthesis of prostaglandins and thromboxanes in organs and microsomal fractions of various animal species (rat, pig, rabbit). NG is an inhibitor of platelet aggregation in vitro dependent on NG dose and platelet activator. NG is able to disaggregate ADP-induced platelet aggregation. An increased antiaggregatory(More)