Ulrich Zehl

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In two groups of medical students (group A n=13, group B n=9, aged 23 to 28 years) we estimated the levels of PGE, PGF2 alpha, 6-keto-PGF1 alpha and thromboxane(TX)B2 by means of radioimmunoassay in the peripheral venous blood immediately before (BES) and 15-30 min after (AES) examination stress and compared these to control levels. Furthermore we(More)
Male Wistar rats received for 4 weeks a linoleic acid (LA) rich (13.3 cal. % LA) or an LA deficient (0.5 cal. % LA) diet as well as 1.5% sodium chloride as drinking fluid. Compared with the LA rich diet the LA deficient diet caused an increase in blood pressure of about 10 mmHg. Indomethacin treatment (2 X 1 mg/kg/day s.c.) increased the blood pressure in(More)
1 The influence of prostacyclin (PGI2) on the release of adenosine in rabbit hearts perfused by the Langendorff method was examined under normal conditions of perfusion and during perfusion with the adenosine antagonist, aminophylline. 2 PGI2 increased both coronary flow and the myocardial release of adenosine in a dose-dependent manner. Aminophylline at a(More)
All vasodilatory drugs reported in this chapter possess an antiaggregatory effect on platelets, some of them with a synergistic effect on prostacyclin-induced inhibition of aggregation. Thus, the question seems valid whether the antiaggregatory effect represents one part of their antianginal and antihypertensive action. Some vasodilators stimulate the(More)
The influence of the antianginal drug trapidil on the biosynthesis of thromboxane A2 (TXA2) and/or prostacyclin (PGI2), metabolites of arachidonic acid (AA), was investigated in rabbit and human platelet rich plasma (PRP), in homogenates of rabbit spleen and of rat lung and in aortic preparations of rats and rabbits, respectively. Trapidil showed a marked(More)
There is a simple method of inducing cardiopulmonary dysfunction in rats through platelet aggregation after rapid i.v. administration of ADP and thrombin. Infusion of 25 ng/min/kg PGI2 completely inhibited the decrease of both breathing and heart rate induced by 30 IU/kg thrombin. The same PGI2 infusion failed to influence the cardiopulmonary effects of the(More)
The autoregulation behaviour of the coronary circulation was studied on an isolated Langendorff-heart of rabbit. Static pressure-flow curves were recorded for the normal and maximally dilated vascular system. For analyzing the dynamics of autoregulation of the flow to pressure jumps within the autoregulation range was measured. Modelling was performed by(More)