Ulrich Markmann-Mulisch

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Genetic recombination pathways and genes are well studied, but relatively little is known in plants, especially in lower plants. To study the recombination apparatus of a lower land plant, a recombination gene well characterized particularly in yeast, mouse, and man, the RAD51 gene, was isolated from the moss Physcomitrella patens and characterized. Two(More)
We report the identification of a novel mouse cDNA encoding IAP38, a putative plasma membrane protein of 38 kDa in splenic macrophages, B cells and T cells. The expression of iap38 is induced by blood-stage infections of Plasmodium chabaudi malaria and is testosterone-sensitive in non-immune mice. However, when mice have acquired testosterone-resistant(More)
RAD51, the eukaryotic homolog of the bacterial RecA recombinase, plays a central role in homologous recombination (HR) in yeast and animals. Loss of RAD51 function causes lethality in vertebrates but not in other animals or in the flowering plant Arabidopsis thaliana, suggesting that RAD51 is vital for highly developed organisms but not for others. Here, we(More)
The eukaryotic RecA homologue RAD51 plays an essential role in homologous recombination and DNA damage repair in yeast. The lethality of rad51 mutants in vertebrates suggests that this gene has acquired additional functions at the interface of recombination and cell-cycle control in some animals. However, viability and unaltered vegetative development in a(More)
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