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Antidepressants inhibit the re-uptake of norepinephrine at the monoaminergic synapse from the synaptic fissure, leading in this way to an increased sensitivity to catecholamines. In addition, antidepressants have alpha1-, H1- and H2-receptor blocking effects and also anticholinergic effects; the tricyclic antidepressants in particular are known for these(More)
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