Ulrich Drews

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The distribution of androgen and estrogen binding sites in the mouse epididymis was assessed by autoradiography with 3H dihydrotestosterone (3H DHT) and 3H estradiol (3H E2). Nuclear labeling with 3H DHT in principal cells of the epithelium is high in the caput, low in the corpus, and high again in the cauda. 3H E2 also binds to the nuclei of principal(More)
In mammals formation of a sinus vagina is inhibited in the male by endogenous testosterone from the embryonic testes. To answer the question which morphogenetic events during formation of the vagina are influenced by testosterone, we explanted genital tracts of mouse embryos in the indifferent stage of development in organ culture. Half of the explants were(More)
The X-linked Tfm mutation causes androgen insensitivity in the target cells of testosterone. Due to random X-inactivation, XX-mice heterozygous for Tfm are mosaics in respect to androgen sensitivity. By the autosomal “sex reversal” mutation, Tfm-heterozygotes were converted to males during embryonic life so that male sex organs developed in which the mosaic(More)
OBJECTIVE The aim of this study was to review the surgical transobturator vaginal tape inside-out (Gynecare TVT-O, Ethicon Inc., Somerville, NJ) technique as described by de Leval and to present the relevant anatomical conditions of the lower pelvis on the basis of corpse dissections after TVT-O placement. STUDY DESIGN In order to visualize the anatomical(More)
In this report we characterize muscarinic cholinergic receptor on embryonic cells. We established dose-response curves by fluorometric measurement of Ca2+ mobilization in cell suspensions of whole chick embryos stage 23/24. Ca2+ mobilization was quantitated by standardization of chlorotetracycline (CTC) fluorescence changes after stimulation with muscarinic(More)
In melanoma cells of primary and metastatic human melanomas muscarinic cholinergic receptors are present. Muscarinic receptors were shown to be expressed in morphogenetically active embryonic cells. Therefore, the possibility exists that in melanomas an embryonic trait is re-expressed after transformation. In the present study, we demonstrated the presence(More)
In embryos morphogenetically active cells transiently express the cholinergic system comprising cholinesterase activity and muscarinic acetylcholine receptors. Malignant melanomas develop from melanocytes, which are derived from the neural crest. Neural crest cells express the embryonic muscarinic system during migration. Using the monoclonal antibody M35,(More)
In a previous immunohistochemical study we observed muscarinic acetylcholine receptors in primary and metastatic human melanomas, which were not present in normal skin melanocytes. In the present study we demonstrated the endogenous expression of muscarinic receptors, of choline acetyltransferase and of cholinesterase activity in the human melanoma cell(More)
The mechanism of excitation contraction coupling during morphogenetic movements is unknown. We describe a contraction wave in the chick blastoderm after muscarinic stimulation, which indicates that an autocrine cholinergic mechanism might be involved in the induction of morphogenetic movements during embryogenesis. Chick blastoderms were explanted in a(More)
Sex reversed mice are XX males carrying on one of their X chromosomes a translocation of the sex determining region of the Y (Cattanach's Sxr factor). The phenotype corresponds to the Klinefelter syndrome in man. The X linked Tfm (testicular feminization) mutation in the mouse is a frame shift in the androgen receptor gene leading to complete androgen(More)