Ulrich Bockelmann

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We describe an approach to substituting a fluorescence microarray with a surface made of an arrangement of electrolyte-gated field effect transistors. This was achieved using a dedicated blocking of non-specific interactions and comparing threshold voltage shifts of transistors exhibiting probe molecules of different base sequence. We apply the approach to(More)
A striking feature of the alpha-hemolysin channel-a prime candidate for biotechnological applications-is the dependence of its ionic conductance on the magnitude and direction of the applied bias. Through a combination of lipid bilayer single-channel recording and molecular dynamics (MD) simulations, we characterized the current-voltage relationship of(More)
Le paysage de l'UMR 7083, constitué jusque-là des équipes "Physico-Chimie Théorique" (PCT) et "Microfluidique, MEMS et Nanostructures" (MMN), s'est considérablement modifié en 2005 grâce à l'arrivée de l'équipe "Nanobiophysique" (NBP) dirigée par Ulrich Bockelmann. Les recherches de cette équipe, composée de physiciens, portent sur les molécules d'ADN et(More)
We use optical tweezers to control the folding and unfolding of individual DNA and RNA hairpins by force. Four hairpin molecules are studied in comparison: two DNA and two RNA ones. We observe that the conformational dynamics is slower for the RNA hairpins than for their DNA counterparts. Our results indicate that structures made of RNA are dynamically more(More)
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