Ulla Karjalainen

Learn More
Disc degeneration (DD) is a common condition that progresses with aging. Although the events leading to DD are not well understood, a significant genetic influence has been found. This study was undertaken to assess the association between relevant candidate gene polymorphisms and moderate DD in a well-defined and characterized cohort of young adults.(More)
The applicability of capillary electrophoresis (CE) with UV and mass spectrometric (MS) detection for the determination of dopamine and methoxycatecholamines in urine was evaluated in comparison with the liquid chromatography-electrochemical detection (LC-EC) method widely used in catecholamine analysis. The catecholamines in urine were deconjugated with(More)
Highly emetogenic drugs such as cisplatin induce an increase in the urinary 5-hydroxyindoleacetic acid (5-HIAA) level, the main metabolite of serotonin (5-HT), within the first 24 h following a single infusion, thus providing a possible cause for acute emesis and an explanation for the action of 5-HT3 antagonists. No further excretion peaks have been(More)
Asian agriculture has made enormous gains in food production despite rapid population growth and a shortage of land. This paper reviews the role of fertilizer in agricultural production and the results of recent research on fertilizers and plant nutrition in the region. Fertilizer use has contributed greatly to the increase in food production which has(More)
During the last six years there has been a marked change in the nature of interlaboratory variance in enzyme determinations in Finland. With ordinary two-dimensional plotting methods the change is difficult to see, because enzyme activities are different for each control serum. The decrease in the coefficient of variation (CV) is best seen when the CV is(More)
Using 123 specimens, we compared the concordance of three different methods for determining glycohemoglobin (GHb): the Diamat (Bio-Rad Laboratories), an automated analyzer measuring HbA1c by cation-exchange chromatography; an assay with the IMx analyzer (Abbott Laboratories), based on boronate affinity binding; and an HPLC method measuring HbA1c by(More)
We here report the characteristics of two rare a-chain hemoglobin (Hb) variants. The variants were found during quantification of HbAic by cation-exchange HPLC with the DiamatTM glycohemoglobin analyzer. They were further characterized by isoelectric focusing and P0IyCAT A cation-exchange chromatography. The structure of the abnormal Hbs was established by(More)
The concept of reference values can be extended to multidimensional results. A probability function describes the relative density of the observations in the multivariate space. When the density of a given point is measured relative to all other points, we get an estimate of the density rank of a given point. If the rank of a point is lower than 95 per cent(More)