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OBJECTIVE Breast milk fatty acids may have immunomodulatory properties related to the development of atopic disease. The aim of this study was to assess the impact of the breast milk fatty acid composition on the development of atopic dermatitis (AD) in high-risk infants. METHODS Mothers with atopic disease were recruited at the end of gestation. Maternal(More)
OBJECTIVE To evaluate food and nutrient intake and especially eating during the school day among Finnish secondary-school pupils. DESIGN Cross-sectional study. Data were collected using a structured questionnaire mailed to home and by 48 h dietary recall interviews performed at schools in 2007. SETTING Twelve schools in three cities in Finland. (More)
The aim of the study was to assess the quantitative and qualitative differences of the gut microbiota in infants. We evaluated gut microbiota at the age of 6 months in 32 infants who were either exclusively breast-fed, formula-fed, nursed by a formula supplemented with prebiotics (a mixture of fructo- and galacto-oligosaccharides) or breast-fed by mothers(More)
PURPOSE Breast milk fatty acids possess immunomodulatory properties, and new intervention strategies beyond supplementation of maternal diet with single oils are called for. The objective of the present study was to evaluate the effect of dietary intervention during pregnancy and breastfeeding on breast milk fatty acid and cytokine composition. METHODS(More)
BACKGROUND The hTAS2R38 taste receptor genotype is related to bitter taste perception and thus may affect food preferences. The present study aimed to evaluate the relationship between the hTAS2R38 genotype and the food consumption and nutrient intakes of Finnish children aged 2-6 years. METHODS Dietary intake was assessed with 7-day food records, and DNA(More)
The challenge for the modern health care system is to fight against the increasing prevalence of atopic disease. The introduction of scientifically composed probiotic functional foods for prophylactic or therapeutic purposes could be one solution. Probiotics are live microbial food supplements or components of bacteria which have beneficial effects on human(More)
OBJECTIVE To decrease the intake of sucrose, increase the intake of fibre and the consumption of fruit and vegetables among secondary-school pupils. DESIGN Intervention study among eighth grade pupils during one school year. Data were collected by questionnaires and from a subgroup of pupils by 48 h dietary recall at baseline in spring 2007 and after the(More)
OBJECTIVE To investigate the impact of maternal diet during breastfeeding on atopic sensitization of infants at risk. DESIGN Prospective cohort study. SETTING Turku University Central Hospital, Finland. SUBJECTS AND METHODS Altogether 114 infants with a family history of atopic disease were followed during their first year of life. The mothers(More)
In addition to its role in sensing intraluminal microbial antigens, soluble (s)CD14 may regulate immune responses by its lesser known function as a lipid carrier with possible influences in the production of fatty acid-derived eicosanoids. We investigated the interrelations of fatty acids, prostaglandin E2 (PGE2), and sCD14 and their role in infant atopic(More)
OBJECTIVE To assess the effects of maternal dietary and supplement intake of vitamins C and E on breast milk antioxidant composition (vitamin C, alpha-tocopherol and beta-carotene) and their protective potential against the development of atopy in the infant. DESIGN, SUBJECTS AND METHODS Mothers with atopic disease were recruited at the end of gestation(More)