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Non-targeted UHPLC-MS metabolomic data processing methods: a comparative investigation of normalisation, missing value imputation, transformation and scaling
We assess the influence of normalisation, missing value imputation, transformation and scaling methods on univariate and multivariate analysis of UHPLC-MS datasets acquired for different mammalian samples. Expand
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(1)H NMR metabolomics reveals contrasting response by male and female mussels exposed to reduced seawater pH, increased temperature, and a pathogen.
Human activities are fundamentally altering the chemistry of the world's oceans. Ocean acidification (OA) is occurring against a background of warming and an increasing occurrence of diseaseExpand
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Structure and function of BamE within the outer membrane and the β‐barrel assembly machine
Insertion of folded proteins into the outer membrane of Gram‐negative bacteria is mediated by the essential β‐barrel assembly machine (Bam). Here, we report the native structure and mechanism of aExpand
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Characterization of isotopic abundance measurements in high resolution FT-ICR and Orbitrap mass spectra for improved confidence of metabolite identification.
Currently there is limited information available on the accuracy and precision of relative isotopic abundance (RIA) measurements using high-resolution direct-infusion mass spectrometry (HR DIMS), andExpand
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Mass spectrometry based environmental metabolomics: a primer and review
Environmental metabolomics can be described as the study of the interactions of living organisms with their natural environments at the metabolic level. Until recently, nuclear magnetic resonanceExpand
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The metabolic response of marine copepods to environmental warming and ocean acidification in the absence of food
Marine copepods are central to the productivity and biogeochemistry of marine ecosystems. Nevertheless, the direct and indirect effects of climate change on their metabolic functioning remain poorlyExpand
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Identification of Chaoborus kairomone chemicals that induce defences in Daphnia
Infochemicals play important roles in aquatic ecosystems. They even modify food web interactions, such as by inducing defenses in prey. In one classic but still not fully understood example, theExpand
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Wolbachia Modulates Lipid Metabolism in Aedes albopictus Mosquito Cells
ABSTRACT Certain strains of the intracellular endosymbiont Wolbachia can strongly inhibit or block the transmission of viruses such as dengue virus (DENV) by Aedes mosquitoes, and the mechanismsExpand
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Biodiversity in marine invertebrate responses to acute warming revealed by a comparative multi‐omics approach
Abstract Understanding species' responses to environmental change underpins our abilities to make predictions on future biodiversity under any range of scenarios. In spite of the huge biodiversity inExpand
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A Stable-Isotope Mass Spectrometry-Based Metabolic Footprinting Approach to Analyze Exudates from Phytoplankton
Phytoplankton exudates play an important role in pelagic ecology and biogeochemical cycles of elements. Exuded compounds fuel the microbial food web and often encompass bioactive secondaryExpand
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