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The analysis of the three-dimensional (3-D) structure of tumoral invasion fronts of carcinoma of the uterine cervix is the prerequisite for understanding their architectural-functional relationship. The variation range of the invasion patterns known so far reaches from a smooth tumor-host boundary surface to more diffusely spreading patterns, which all are(More)
PURPOSE Prostate cancer is routinely graded according to the Gleason grading scheme. This scheme is predominantly based on the textural appearance of aberrant glandular structures. Gleason grade is difficult to standardize and often leads to discussion due to interrater and intrarater disagreement. Thus, we investigated whether digital image based automated(More)
BACKGROUND Radical hysterectomy based on empirical surgical anatomy to achieve a wide tumour resection is currently applied to treat early cervical cancer. Total mesometrial resection (TMMR) removes the embryologically defined uterovaginal (Müllerian) compartment except its distal part. Non-Müllerian paracervical and paravaginal tissues may remain in situ(More)
OBJECTIVES The aim of this study was to determine the frequency of diaphragm involvement (DI) in cases of International Federation of Gynecology and Obstetrics (FIGO) stage IIIC and IV primary epithelial ovarian, fallopian tube, or peritoneal cancer; the frequency of use of different surgical techniques in managing diaphragm implants; and the(More)
physiologically motivated (see [15]) colour space corresponds to the deviation in illumination from typical daylight. By a process, the cluster is transformed so that its elongation will be along the achromatic axis. So we can ensure equal colour sensations under different lighting conditions (see 1st and 2nd figure below). The skin colour classification(More)
We present a neural architecture for gesture-based interaction between a mobile robot and human users. One crucial problem for natural interface techniques is the robustness under highly varying environmental conditions. Therefore, we propose a multiple cue approach for the localisation of a potential user in the operation eld, followed by the aquisition(More)
Astroglial cells in the central nervous system (CNS) are able to change their morphology and shape after different kinds of stimuli. We have developed a method for the structural description of astrocytes based on their representation as undirected simple graphs. The underlying image processing chain and the algorithm for the graph construction are(More)
BACKGROUND Analyses of the pore size distribution in 3D matrices such as the cell-hydrogel interface are very useful when studying changes and modifications produced as a result of cellular growth and proliferation within the matrix, as pore size distribution plays an important role in the signaling and microenvironment stimuli imparted to the cells.(More)
BACKGROUND Malignant growth and invasiveness of cancers is a function of both intratumoral and stromal factors. The accessibility to nutrients, oxygen and growth factors, the stromal composition, and the interference with the immune system all shape the tumor invasion front. A recent study has shown a prognostic difference with respect to different invasion(More)
Adipose tissue engineering has been advocated for soft-tissue augmentation and for the treatment of soft tissue defects. The efficacy in terms of persistence of the engineered fat is, however, not yet understood and could depend on the nature of fabrication and application. The high metabolic demand of adipose tissue also points to the problem of(More)