Gabriella Sozzi9
Carla Verri6
9Gabriella Sozzi
6Carla Verri
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An early response to cigarette smoke is an influx of leukocytes into the lung. Alveolar epithelial type II (ATII) cells may contribute by releasing chemokines in response to cigarette smoke and neutrophil elastase (NE). Human ATII cells were purified from normal regions of lungs resected for carcinoma (n = 14). In vitro, these cells exhibited ATII cell(More)
PURPOSE Whole-genome scan association analysis was carried out to identify genetic variants predictive of lung cancer risk in smokers and to confirm the identified variants in an independent sample. PATIENTS AND METHODS A case-control study was performed using two pools consisting of DNA from 322 German smoking lung cancer patients and 273 healthy smoking(More)
Immunoreactivity for fascin, an actin-bundling protein related to cell motility, has been reported in breast, ovary, pancreas, skin, and non-small cell carcinomas, and associated with more advanced disease stage and poorer prognosis. Data on pulmonary neuroendocrine (NE) tumors, however, are lacking. We evaluated the expression of fascin by(More)
Lung cancer is the most common cause of cancer deaths worldwide and numerous ongoing research efforts are directed to identify new strategies for its early detection. The development of non-invasive blood-based biomarkers for cancer detection in its preclinical phases is crucial to improve the outcome of this deadly disease. MicroRNAs (miRNAs) are a new(More)
  • Monica Spinola, Antonella Galvan, Carmen Pignatiello, Barbara Conti, Ugo Pastorino, Bjorn Nicander +2 others
  • 2005
tRNA-isopentenyltransferase (tRNA-IPT) catalyses the addition of N6-isopentenyladenosine (i6A) on residue 37 of tRNA molecules that bind codons starting with uridine. Post-transcriptional modifications of tRNA molecules have been demonstrated to be essential in maintaining the correct reading frame of the translational machinery, thus improving fidelity and(More)
PURPOSE Spiral computed tomography (CT) can detect lung cancer at an early stage, but the malignant potential is unknown. The question is, as follows: do these small lesions have the same lethal potential as do symptomatic tumors? EXPERIMENTAL DESIGN We used a cDNA microarray platform and compared the gene expression profile of spiral CT-detected lung(More)
  • Maria Moksnes Bjaanæs, Ann Rita Halvorsen, Steinar Solberg, Lars Jørgensen, Tommaso A Dragani, Antonella Galvan +7 others
  • 2014
The findings of mutations and the development of targeted therapies have improved lung cancer management. Still, the prognosis remains poor, and we need to know more about the genetic and epigenetic alterations in lung cancer. MicroRNAs are involved in crucial biological processes like carcinogenesis by regulating gene expression at the post-transcriptional(More)
RATIONALE Free circulating plasma DNA has emerged as a potential biomarker for early lung cancer detection. In a previous case-control study we have shown that high levels of plasma DNA are a strong risk factor for lung cancer. OBJECTIVES To assess the diagnostic performance and prognostic value of plasma DNA levels in a cohort of 1,035 heavy smokers(More)