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 Liver biopsy is an invasive diagnostic method for detecting liver involvement (LI) in Hodgkin's disease (HD). The aim of this retrospective study was to determine and evaluate a method for restricting liver biopsy to a subset of patients. Between 1988 and 1994, a total of 2016 patients with HD were treated within the HD4–6 study protocol of the German(More)
Electron microscopy of nervous tissue requires on the one hand nanometre resolution for the analysis of fine structures of nerve cell contacts, for instance synaptic vesicles, synaptic membranes and associated organelles. On the other hand, the visualization of the three-dimensional organization of nervous tissue on the level of dendrites and neurites is(More)
To compare efficacy and toxicity of a sequential HDCT and a standard HDCT in patients with histologically confirmed relapsed Hodgkin’s disease. Primary endpoint of the study is freedom from treatment failure (FFTF) in both treatment arms. Secondary endpoints are complete remission (CR), complete remission unconfirmed (CRu) rates 3 months after end of(More)
Cichlid fish larvae were reared from hatching to active free swimming under different gravity conditions: natural environment, increased acceleration in a centrifuge, simulated weightlessness in a clinostat and near weightlessness during space flight. Cytochrome oxidase activity was analyzed semiquantitatively on the ultrastructural level as a marker of(More)
The mitochondrial enzyme, cytochrome oxidase, was localized cytochemically in the nucleus magnocellularis, a primary relay nucleus of vestibular information within the area octavolateralis in the fish brain. Cichlid fish larvae were analyzed after long-term exposure (9 days) to altered gravity situations: increased acceleration in a centrifuge (3 g) and(More)
The mitochondrial enzyme, cytochrome oxidase, was localized cytochemically in the nucleus magnocellularis, a primary relay nucleus of vestibular information within the area octavolateralis in the fish brain. Larvae of the cichlid fish Oreochromis mossambicus were analyzed at different developmental stages (4, 10, and 35 days post-hatching) and after(More)
Durch das 12. Gesetz zur Änderung des Arzneimittelgesetzes (im Folgenden 12. AMG-Novelle) erfolgt eine Umsetzung der europäischen Richtlinie 2001/20/EG in deutsches Recht. Deren Ziel ist die Verankerung der guten klinischen Praxis (Good Clinical Practice, GCP) in die Gesetzgebung als ethischer und wissenschaftlicher Maßstab zur Planung, Durchführung,(More)
Bei der Planung der 3. und 4. Studiengeneration der Deutschen Hodgkin Lymphom Studiengruppe (DHSG) kamen erstmals in größerem Umfang neue biometrische Methoden zum Einsatz, die es erlaubten, die Konzeption neuer klinischer Studien auf ein theoretisch gut begründetes Fundament aufzubauen und inzwischen nachgewiesene Effekte richtig vorauszusagen.(More)
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