Udaya W DeSilva

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BACKGROUND The role for endometrial secretion of cytokines during the establishment of pregnancy in a number of mammals is well established. The current study determined endometrial expression of caspase 1 (CASP1) and interleukin-18 (IL18) during the estrous cycle and early pregnancy, and following early estrogen administration, which induces conceptus loss(More)
Williams syndrome is a complex developmental disorder that results from the heterozygous deletion of a ∼1.6-Mb segment of human chromosome 7q11.23. These deletions are mediated by large (∼300 kb) duplicated blocks of DNA of near-identical sequence. Previously, we showed that the orthologous region of the mouse genome is devoid of such duplicated segments.(More)
BACKGROUND MicroRNAs (miRNAs) are small ~22-nt regulatory RNAs that can silence target genes, by blocking their protein production or degrading the mRNAs. Pig is an important animal in the agriculture industry because of its utility in the meat production. Besides, pig has tremendous biomedical importance as a model organism because of its closer proximity(More)
iii ACKNOWLEDGEMENTS " But seek first His kingdom and His righteousness and all these things will be given to you as well. " Mathew 6:33. I thank God for keeping His promise as I continued to be faithful to Him over the last three and a half years of my stay and study in United States. The first person whom I would like to thank is my major advisor Dr.(More)
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