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Ubiquitin‐specific protease‐like 1 (USPL1) is a SUMO isopeptidase with essential, non‐catalytic functions
Isopeptidases are essential regulators of protein ubiquitination and sumoylation. However, only two families of SUMO isopeptidases are at present known. Here, we report an activity‐based search withExpand
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A Conserved Membrane Attachment Site in α-SNAP Facilitates N-Ethylmaleimide-sensitive Factor (NSF)-driven SNARE Complex Disassembly*
The ATPase NSF (N-ethylmaleimide-sensitive factor) and its SNAP (soluble N-ethylmaleimide-sensitive factor attachment protein) cofactor constitute the ubiquitous enzymatic machinery responsible forExpand
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Regulated Shedding of Transmembrane Chemokines by the Disintegrin and Metalloproteinase 10 Facilitates Detachment of Adherent Leukocytes1
CX3CL1 (fractalkine) and CXCL16 are unique members of the chemokine family because they occur not only as soluble, but also as membrane-bound molecules. Expressed as type I transmembrane proteins,Expand
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A role for the Cajal-body-associated SUMO isopeptidase USPL1 in snRNA transcription mediated by RNA polymerase II
ABSTRACT Cajal bodies are nuclear structures that are involved in biogenesis of snRNPs and snoRNPs, maintenance of telomeres and processing of histone mRNA. Recently, the SUMO isopeptidase USPL1 wasExpand
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A novel site of action for alpha-SNAP in the SNARE conformational cycle controlling membrane fusion.
Regulated exocytosis in neurons and neuroendocrine cells requires the formation of a stable soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex consisting ofExpand
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A Novel Site of Action for α-SNAP in the SNARE Conformational Cycle Controlling Membrane Fusion
Regulated exocytosis in neurons and neuroendocrine cells requires the formation of a stable soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex consisting ofExpand
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Imaging the assembly and disassembly kinetics of cis‐SNARE complexes on native plasma membranes
Mild sonication of eukaryotic cells produces native plasma membrane sheets that retain their docked organelles, cytoskeleton structures and cytoplasmic complexes. While the delicate organization ofExpand
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The Application of Salutogenesis in Hospitals
We relate Antonovsky’s concepts of salutogenesis (Antonovsky, 1979; 1993) to the hospital setting. We argue that salutogenesis is particularly challenging to this setting—and vice versa. However, weExpand
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Hydrogen Automobile Heads Toward Series Production HydroGen3 Puts Fuel Cells on the Road
General Motor's concept vehicle HydroGen3, based on the Opel Zafira production model, represents the third generation of fuel cell concept vehicles. Groundbreaking new technical and engineeringExpand
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Hydrogen for the Mobility of the Future Results of GM/Opel's Well‐to‐Wheel Studies in North America and Europe
General Motors conducted two well-to-wheel studies for fundamental clarification on the question of which is the cleanest and most environmentally sustainable source of energy for the mobility of theExpand
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