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Common Genetic Determinants of Intraocular Pressure and Primary Open-Angle Glaucoma
TLDR
GAS7 and TMCO1 are highly expressed in the ciliary body and trabecular meshwork as well as in the lamina cribrosa, optic nerve, and retina, and both genes functionally interact with known glaucoma disease genes. Expand
The protective effect of quercetin against oxidative stress in the human RPE in vitro.
TLDR
It is demonstrated that quercetin is able to protect RPE cells from oxidative damage and cellular senescence in vitro in a dose-dependent manner and the authors suggest that this increase in antioxidative capacity is mediated by inhibiting the upregulation of caveolin-1. Expand
Bone morphogenetic protein-7 is an antagonist of transforming growth factor-beta2 in human trabecular meshwork cells.
TLDR
BMP-7 strongly antagonizes in vitro the TGF-beta-induced expression of a broad panel of molecules, which would result in an accumulation of TM ECM in situ, which might be a promising strategy to treat POAG. Expand
Posterior vitreous detachment induced by microplasmin.
TLDR
Both after death and in vivo, microplasmin induces a dose-dependent cleavage between the vitreous cortex and the ILM without morphologic alterations of the retina in the feline eye. Expand
Connective tissue growth factor induces extracellular matrix deposition in human trabecular meshwork cells.
TLDR
The results indicate that treatment of human TM cells with recombinant CTGF causes distinct changes in gene expression and that CTGF is a critical mediator of the effects of TGF-beta2 on ECM synthesis inhuman TM cells. Expand
The prostaglandin transporter OATP2A1 is expressed in human ocular tissues and transports the antiglaucoma prostanoid latanoprost.
TLDR
The results presented herein suggest that at least OATP2A1 plays a role in the intraocular disposition of the therapeutically used prostanoid latanoprost. Expand
Thrombospondin-1 in the trabecular meshwork: localization in normal and glaucomatous eyes, and induction by TGF-beta1 and dexamethasone in vitro.
TLDR
TSP-1 in the TM might act as a potent local endogenous activator of TGF-betas in the aqueous humor and mediate any local effects of T GF-beta and/or dexamethasone on the outflow of aqueously humor. Expand
Effects of oxidative stress in trabecular meshwork cells are reduced by prostaglandin analogues.
TLDR
Oxidative stress is able to induce characteristic glaucomatous TM changes in vitro, and these oxidative stress-induced TM changes can be minimized by the use of prostaglandin analogues. Expand
The effect of TGF-beta2 on elastin, type VI collagen, and components of the proteolytic degradation system in human optic nerve astrocytes.
TLDR
TGF-beta2 induces expression of elastin and ColVI and thereby could contribute to the increase of type VI collagen fibers in the tissue septae and the elastotic changes typically observed in POAG. Expand
Induction of Tissue Transglutaminase in the Trabecular Meshwork by TGF-β1 and TGF-β2
TLDR
The enzyme tTgase is expressed in the HTM and is inducible by TGF-beta1 or -beta2 in cultured HTM cells, causing an increase of irreversibly cross-linked ECM proteins. Expand
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