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Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer.
BACKGROUND We conducted 20 years of follow-up of women enrolled in a randomized trial to compare the efficacy of radical (Halsted) mastectomy with that of breast-conserving surgery. METHODS FromExpand
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A randomized comparison of sentinel-node biopsy with routine axillary dissection in breast cancer.
BACKGROUND Although numerous studies have shown that the status of the sentinel node is an accurate predictor of the status of the axillary nodes in breast cancer, the efficacy and safety ofExpand
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Intraoperative radiotherapy versus external radiotherapy for early breast cancer (ELIOT): a randomised controlled equivalence trial.
BACKGROUND Intraoperative radiotherapy with electrons allows the substitution of conventional postoperative whole breast irradiation with one session of radiotherapy with the same equivalent doseExpand
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Axillary dissection versus no axillary dissection in patients with sentinel-node micrometastases (IBCSG 23-01): a phase 3 randomised controlled trial.
BACKGROUND For patients with breast cancer and metastases in the sentinel nodes, axillary dissection has been standard treatment. However, for patients with limited sentinel-node involvement,Expand
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Sentinel-node biopsy to avoid axillary dissection in breast cancer with clinically negative lymph-nodes
BACKGROUND Axillary lymph-node dissection is an important staging procedure in the surgical treatment of breast cancer. However, early diagnosis has led to increasing numbers of dissections in whichExpand
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Combination chemotherapy as an adjuvant treatment in operable breast cancer.
Prolonged cyclic combination chemotherapy with cyclophosphamide, methotrexate and fluorouracil was evaluated as adjuvant treatment to radical mastectomy in primary breast cancer with positiveExpand
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Sentinel‐Node Biopsy to Avoid Axillary Dissection in Breast Cancer with Clinically Negative Lymph‐Nodes
Background. Axillary lymph-node dissection is an important staging procedure in the surgical treatment of breast cancer. However, early diagnosis has led to increasing numbers of dissections in whichExpand
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Radiotherapy after breast-preserving surgery in women with localized cancer of the breast.
BACKGROUND AND METHODS Conservative surgery and radiotherapy have become well-established treatments for breast cancer, and many trials in progress are attempting to define the most acceptable typeExpand
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Ductal lavage for detection of cellular atypia in women at high risk for breast cancer.
BACKGROUND Breast cancer originates in breast epithelium and is associated with progressive molecular and morphologic changes. Women with atypical breast ductal epithelial cells have an increasedExpand
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Radiotherapy after breast-conserving surgery in small breast carcinoma: long-term results of a randomized trial.
BACKGROUND Breast-conserving surgery followed by radiotherapy is a widely accepted form of treatment in patients with breast cancer of limited extent. Many attempts have been made to identifyExpand
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