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Innate immunity and its evasion and suppression by hymenopteran endoparasitoids
TLDR
It is suggested that host–parasitoid systems are important experimental models for studying how the innate immune system of insects recognizes foreign invaders that are phylogenetically more closely related to their hosts. Expand
Coagulation, an ancestral serine protease cascade, exerts a novel function in early immune defense.
TLDR
Bacterial killing and cross-linking to fibrin networks was also detected in tissue biopsies from patients with streptococcal necrotizing fasciitis, supporting the concept that coagulation is part of the early innate immune system. Expand
Isolation and Characterization of Hemolymph Clotting Factors in Drosophila melanogaster by a Pullout Method
TLDR
It is shown that clotting occurs in the absence of phenoloxidase and that the Drosophila clot binds bacteria, and it is confirmed that hemolectin mutant larvae show clotting defects. Expand
Pathogen Entrapment by Transglutaminase—A Conserved Early Innate Immune Mechanism
TLDR
The results firmly establish the hemolymph/blood clot as an important effector of early innate immunity, which helps to prevent septic infections and will help to guide further strategies to reduce the damaging effects of clotting and enhance its beneficial contribution to immune reactions. Expand
Coagulation in arthropods: defence, wound closure and healing.
TLDR
The well-characterized clotting cascade in horseshoe crabs is strongly activated by bacterial elicitors, in contrast to vertebrate clotting where induction relies more on endogenous signals. Expand
Proteomic Analysis of the Drosophila Larval Hemolymph Clot*
TLDR
A proteomic comparison of larval hemolymph before and after clotting is presented to learn more about this process and allows the isolation of novel candidate clotting factors, leading to a more complete picture of clotting. Expand
Crystal cell rupture after injury in Drosophila requires the JNK pathway, small GTPases and the TNF homolog Eiger
TLDR
This work shows that prophenoloxidase release requires Jun N-terminal kinase, small Rho GTPases and Eiger, the Drosophila homolog of tumor necrosis factor, and that this process can be inhibited in vitro and in vivo using the viral apoptotic inhibitor p35. Expand
Activation of Insect Phenoloxidase after Injury: Endogenous versus Foreign Elicitors
TLDR
Interestingly, unlike systemic PO activation during bacterial sepsis, clot melanization was not sensitive to microbial elicitors in the authors' assay and shows that both exogenous and endogenous signals can trigger the same immune mechanism in species- and context-dependent ways. Expand
Helix pomatia lectin and annexin V, two molecular probes for insect microparticles: possible involvement in hemolymph coagulation.
TLDR
Evidence for the presence of microparticles in the coagulation reaction of Drosophila hemocytes is presented and hemomucin is shown to bind to lipophorin, a multifunctional hemolymph molecule previously implied in coagulating. Expand
The coagulation of insect hemolymph
TLDR
The factors of the well-characterized clotting cascades of vertebrates, primitive chelicerates and crustaceans are used to assess the implications of sequencing the whole Drosophila genome for searching candidate genes involved in hemostasis. Expand
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