U. Seemüller

Publications20
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Citations854
Highly Influential Citations15
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Structure of the elastase-cathepsin G inhibitor of the leech Hirudo medicinalis.
The leech Hirudo medicinalis contains three different groups of proteinase inhibitor proteins, the thrombin-specific hirudin, the bdellins directed against trypsin, plasmin and acrosin, and the…
The acid‐stable proteinase inhibitor of human mucous secretions (HUSI‐I, antileukoprotease)
Isolation and characterisation of a low molecular weight inhibitor (of chymotrypsin and human granulocytic elastase and cathepsin G) from leeches.
TLDR
The eglins are the first examples of proteinase inhibitors of the protein type which are not stabilized by disulfide bridges, and are stable in neutral and weakly acid (pH 3) solutions and resist non-specific proteolysis.
The complete amino acid sequence of hirudin, a thrombin specific inhibitor
Molecular cloning and expression of cDNA for human antileukoprotease from cervix uterus.
TLDR
Two overlapping cDNA clones for the human antileukoprotease HUSI-I, an elastase inhibitor, from a library, containing cDNA inserts made from human cervix uterus, showed that DNA sequence data showed that the clone corresponds with the available protein sequence data.
The complete covalent structure of hirudin. Localization of the disulfide bonds.
TLDR
Hirudin seems to be unique in its primary structure and hence designates an unknown inhibitor family, due to the lack of any closer sequence homology and topological structural homology to other serine proteinase inhibitor proteins.
Eglin c, a pharmacologically active elastase inhibitor.
TLDR
The rate of complex formation between Eglin c and human leukocyte elastase (HLE) or human cathepsin G (H. Cat. G) was determined and compared to those of a number of other proteinase/proteinase-inhibitor interactions (alpha 1 PI and alpha 2M).
Sequence determination of eglin C using combined microtechniques of amino acid analysis, peptide isolation, and automatic Edman degradation.
Isolation and characterization of hirudin isoinhibitors and sequence analysis of hirudin PA.
TLDR
The final purification of two thrombin-inhibiting preparations by reversed-phase high-performance liquid chromatography yielded several isohirudins with either N-terminal valine or isoleucine but with identical inhibition characteristics, i.e. specific throm bin inhibiting activities of 680-720 IU/mg.
Kinetics of the inhibition of human leucocyte elastase by eglin from the leech Hirudo medicinalis.
TLDR
The rate constants for the inhibition of human leucocyte elastase by eglin from the leech Hirudo medicinalis were determined by using a pre-steady-state kinetic approach and the mechanistic properties of the system and the biological significance of the rate constants are discussed.
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