Share This Author
Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-mediated cell death.
Developmental motoneuron cell death and neurotrophic factors
A synopsis of recent data on specific mechanisms underlying neuronal degeneration during development and under pathophysiological conditions in neurodegenerative disorders is presented.
Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis
Selenium and brain function: a poorly recognized liaison
Bag1 is essential for differentiation and survival of hematopoietic and neuronal cells
Targeted gene disruption in mice shows that Bag1 is a physiological mediator of extracellular survival signals linked to the cellular mechanisms that prevent apoptosis in hematopoietic and neuronal progenitor cells.
Gene disruption discloses role of selenoprotein P in selenium delivery to target tissues.
- L. Schomburg, U. Schweizer, B. Holtmann, L. Flohé, M. Sendtner, J. Köhrle
- BiologyThe Biochemical journal
- 1 March 2003
The data reveal that SePP plays a pivotal role in delivering hepatic selenium to target tissues and thatSelenium content was elevated in liver, but low in plasma and other tissues, and selenoenzyme activities changed accordingly.
Neuronal 3′,3,5-Triiodothyronine (T3) Uptake and Behavioral Phenotype of Mice Deficient in Mct8, the Neuronal T3 Transporter Mutated in Allan–Herndon–Dudley Syndrome
It is hypothesized that neurons exclusively dependent on Mct8 are in a hypothyroid state, whereas neurons expressing other T3 transporters become hyperthyroid, if they are exposed directly to the high plasma T3.
Hierarchical regulation of selenoprotein expression and sex-specific effects of selenium.
Conditional gene ablation of Stat3 reveals differential signaling requirements for survival of motoneurons during development and after nerve injury in the adult
The data show that Stat3 activation plays an essential role for motoneuron survival after nerve lesion in postnatal life but not during embryonic development, indicating that signaling requirements for mot oneuron survival change during maturation.
Chemistry and Biology in the Biosynthesis and Action of Thyroid Hormones.
This Review discusses the basic aspects of the chemistry and biology as well as recent advances in the biosynthesis of THs in the thyroid gland, plasma transport, and internalization ofTHs in their target organs, in addition to the deiodination and various other enzyme-mediated metabolic pathways of THS.