U. Schmitz

Publications25
h-index17
Citations868
Highly Influential Citations13
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Structure of the phylogenetically most conserved domain of SRP RNA.
The signal recognition particle (SRP) is a phylogenetically conserved ribonucleoprotein required for cotranslational targeting of proteins to the membrane of the endoplasmic reticulum of the… Expand
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Minor groove DNA binders as antimicrobial agents. 1. Pyrrole tetraamides are potent antibacterials against vancomycin resistant Enterococci [corrected] and methicillin resistant Staphylococcus aureus.
A new series of short pyrrole tetraamides are described whose submicromolar DNA binding affinity is an essential component for their strong antibacterial activity. This class of compounds is related… Expand
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Nuclear magnetic resonance of biological macromolecules
Identification and optimization of protein domains for NMR studies In-cell NMR spectroscopy Molecular Fragment Replacement Approach to Protein Structure Determination by Chemical Shift and Dipolar… Expand
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Probability assessment of conformational ensembles: sugar repuckering in a DNA duplex in solution.
Conformational flexibility of molecules in solution implies that different conformers contribute to the NMR signal. This may lead to internal inconsistencies in the 2D NOE-derived interproton… Expand
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How to generate accurate solution structures of double-helical nucleic acid fragments using nuclear magnetic resonance and restrained molecular dynamics.
Publisher Summary This chapter describes in detail the approach to determine DNA solution structures, with improved accuracy, on the basis of nuclear Overhauser effect (NOE)-derived distance… Expand
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Extracting accurate distances and bounds from 2D NOE exchangeable proton peaks
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Metropolis Monte Carlo calculations of DNA structure using internal coordinates and NMR distance restraints: An alternative method for generating a high-resolution solution structure
SummaryA new method, a restrained Monte Carlo (rMC) calculation, is demonstrated for generating high-resolution structures of DNA oligonucleotides in solution from interproton distance restraints and… Expand
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NMR studies of the most conserved RNA domain of the mammalian signal recognition particle (SRP).
Mammalian signal recognition particle (SRP) and its homologues exhibit a phylogenetically conserved RNA domain, whose predicted secondary structure exhibits a hairpin motif with two bulged regions.… Expand
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Deoxyribose conformation in [d(GTATATAC)]2: evaluation of sugar pucker by simulation of double-quantum-filtered COSY cross-peaks.
Exchangeable and nonexchangeable proton and phosphorus resonances (11.75 T) of [d(GTATATAC)]2 in aqueous solution were assigned by using proton two-dimensional nuclear Overhauser effect (2D NOE)… Expand
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The NMR-mouse: construction, excitation, and applications.
A mobile nuclear magnetic resonance (NMR) device similar to a bore-hole probe has been developed for applications in materials science and biomedicine. Inhomogeneous polarizing and radio-frequency… Expand
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