U. Schibler

Publications240
h-index79
Citations34,331
Highly Influential Citations1,618
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The Orphan Nuclear Receptor REV-ERBα Controls Circadian Transcription within the Positive Limb of the Mammalian Circadian Oscillator
Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus.
TLDR
It is shown that temporal feeding restriction under light-dark or dark-dark conditions can change the phase of circadian gene expression in peripheral cell types by up to 12 h while leaving thephase of cyclic gene expressionIn the SCN unaffected.
SIRT1 Regulates Circadian Clock Gene Expression through PER2 Deacetylation
The mammalian circadian timing system: organization and coordination of central and peripheral clocks.
TLDR
This work discusses knowledge acquired during the past few years on the complex structure and function of the mammalian circadian timing system and some of the SCN output pathways serve as input pathways for peripheral tissues.
A liver-enriched transcriptional activator protein, LAP, and a transcriptional inhibitory protein, LIP, are translated from the sam mRNA
A Serum Shock Induces Circadian Gene Expression in Mammalian Tissue Culture Cells
Resetting of circadian time in peripheral tissues by glucocorticoid signaling.
TLDR
It is shown that the glucocorticoid hormone analog dexamethasone induces circadian gene expression in cultured rat-1 fibroblasts and transiently changes the phase of circadian gene Expression in liver, kidney, and heart, however, dexamETHasone does not affect cyclic geneexpression in neurons of the suprachiasmatic nucleus.
Mammalian Genes Are Transcribed with Widely Different Bursting Kinetics
TLDR
This work established various gene trap cell lines and transgenic cell lines expressing a short-lived luciferase protein from an unstable mRNA, and recorded bioluminescence in real time in single cells, demonstrating that bursting kinetics are highly gene-specific.
Circadian Gene Expression in Individual Fibroblasts Cell-Autonomous and Self-Sustained Oscillators Pass Time to Daughter Cells
Rhythmic CLOCK-BMAL1 binding to multiple E-box motifs drives circadian Dbp transcription and chromatin transitions
TLDR
It is shown that circadian regulation of the mouse albumin D element–binding protein (Dbp) gene involves rhythmic binding of BMAL1 and CLOCK and marked daily chromatin transitions and rhythmic conversion of transcriptionally permissive chromatin to facultative heterochromatin.
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