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Ototoxicity of cis-dichlorodiammine platinum (II) in the guinea pig.
Toxicity of camptothecin (NSC-100880).
Comparison of acute oral toxicity of cannabinoids in rats, dogs and monkeys.
Impaired tunnel-maze behavior in rats with sensory lesions: vestibular and auditory systems.
Since treatment with streptomycin failed to induce any signs of brain lesions, impaired maze learning is considered to result from destruction of Vestibular hair cell receptors with subsequent vestibular impairment and not from hearing loss or cognitive impairment.
Bleomycin-induced interstitial pneumonia in dogs
The intravenous administration of Bleomycin to 10 dogs at different dosages resulted in varying degrees of interstitial pneumonia in all cases and a lower incidence of nephrosis, foot pad excoriation…
cis-Dichlorodiammineplatinum(II) (NSC-119 875): preclinical toxicologic evaluation of intravenous injection in dogs, monkeys and mice.
Validation of a radial maze test for assessing learning and memory in rats.
Pathological effects of bleomycin on the skin of dogs and monkeys.
- J. R. Baker, R. Fleischman, +4 authors R. Davis
- Chemistry, MedicineToxicology and applied pharmacology
- 1 June 1973
In dogs and monkeys, lesions occurred only on footpads and the tail tip, while in monkeys the neck, elbows, cubital fossa, ischial callosities and palmar and plantar surfaces of the hands and feet were affected.
The use of an unbaited tunnel maze in neurotoxicology: I. Trimethyltin-induced brain lesions.
- B. Alessandri, R. E. Fitzgerald, U. Schaeppi, G. Krinke, W. Classen
- Biology, MedicineNeurotoxicology
H hippocampal lesions were induced by injecting animals with the neurotoxicant trimethyltin, and TMT-induced brain lesions led to increased mean error score and number of arm visits during the retention phase and after changing maze configuration, whereas percent "blind-alley" visits were not affected.
Procedures for routine clinical electroretinography (ERG) in dogs
The ERG of the dark-adapted dog, an indicator for the electrical activity of the rod system, was similar with that of man with respect to configuration and other characteristics and different from man by having a 10-fold lower sensitivity and a reduced capability for discrimination of red versus blue or white stimuli.