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Cortical motor reorganization in akinetic patients with Parkinson's disease: a functional MRI study.
Using functional MRI (fMRI), we have studied the changes induced by the performance of a complex sequential motor task in the cortical areas of six akinetic patients with Parkinson's disease and sixExpand
Neural bases of personal and extrapersonal neglect in humans.
The present investigation aimed at exploring the anatomical substrate of both extrapersonal and personal neglect by using different advanced methodological approaches to lesion-function correlation, which suggested a segregation of personal and extrapERSONal spatial awareness in humans. Expand
Aging of subcortical nuclei: Microstructural, mineralization and atrophy modifications measured in vivo using MRI
The statistical analyses highlighted characteristic patterns of variation for the measurements in the various structures evaluated in this study, which contribute in establishing a baseline for comparison with pathological changes in the basal ganglia and thalamus. Expand
The ipsilateral cerebellar hemisphere is overactive during hand movements in akinetic parkinsonian patients.
The results suggest that parkinsonian patients off medication may try to compensate for their basal ganglia-cortical loop's dysfunction using other motor pathways involving cerebellar relays. Expand
Supplementary and primary sensory motor area activity in Parkinson's disease. Regional cerebral blood flow changes during finger movements and effects of apomorphine.
The hypothesis that a functional cortical motor area deafferentation is involved in the pathophysiological makeup of akinesia and that this abnormality is reversed by dopaminergic drugs is supported. Expand
Functional changes in the activity of cerebellum and frontostriatal regions during externally and internally timed movement in Parkinson's disease
Between-group comparison indicates that PD patients OFF medication may compensate for their basal ganglia-cortical loop's dysfunction using different motor pathways involving cerebellum and basalganglia relays during the two phases of rhythmic movement. Expand
Volume and iron content in basal ganglia and thalamus
This work suggests that combining volumetry and iron estimation in MRI permits to investigate in vivo neurophysiological and neuropathological changes of basal ganglia. Expand
Magnetic resonance imaging markers of Parkinson's disease nigrostriatal signature.
Parkinson-associated physiopathological modifications were characterized in six subcortical structures by simultaneously measuring quantitative magnetic resonance parameters sensitive to complementary tissue characteristics, demonstrating that multimodal magnetic resonance imaging of sub cortical grey matter structures is useful for the evaluation of Parkinson's disease and, possibly, of other subcortsical pathologies. Expand
Bilateral Transcranial Direct Current Stimulation Language Treatment Enhances Functional Connectivity in the Left Hemisphere: Preliminary Data from Aphasia
Several studies have already shown that transcranial direct current stimulation (tDCS) is a useful tool for enhancing recovery in aphasia. However, no reports to date have investigated functionalExpand
Parkinson's disease and local atrophy in subcortical nuclei: insight from shape analysis
Testing the hypothesis that changes in local volume detectable with T1-weighted imaging are concomitant with PD and may be used as biomarkers shows that shape analysis contributes valuable information to investigations concerning PD patients and helps to discriminate these patients from control subjects. Expand