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Zebrafish: An Emerging Model System for Human Disease and Drug Discovery
TLDR
This review focuses on zebrafish, Danio rerio, as a facile model system to study human disease and drug responses as a viable addition to established animal models by offering medium and, potentially, high throughput capabilities.
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The EGF receptor - an essential regulator of multiple epidermal functions.
TLDR
The frequent deregulation of EGFR expression and activation in benign and malignant hyperproliferative skin diseases motivates the investigation of EG FR-dependent intracellular pathways which contribute to the varied EGFR-dependent phenotypes.
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Small GTPases and tyrosine kinases coregulate a molecular switch in the phosphoinositide 3-kinase regulatory subunit.
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Tumor-associated transforming growth factor-beta and interleukin-10 contribute to a systemic Th2 immune phenotype in pancreatic carcinoma patients.
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Bovine serum albumin reverses inhibition of RT-PCR by melanin.
TLDR
The addition of >15 μg of bovine serum albumin (BSA) per 25 μL RT-PCR mixture is shown to reverse melanin inhibition, and this modified procedure should allow more effective RT- PCR analysis in melanin-containing cells or tissues.
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Cooperative Induction of a Tolerogenic Dendritic Cell Phenotype by Cytokines Secreted by Pancreatic Carcinoma Cells1
TLDR
An array of pancreatic carcinoma-derived cytokines that cooperatively affect iMo-DC activation in a manner consistent with ineffective antitumor immune responses are identified.
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Molecular cloning of cDNA for the human tumor-associated antigen CO-029 and identification of related transmembrane antigens.
TLDR
Sequence analysis revealed that CO-029 belongs to a family of cell surface antigens that includes the melanoma-associated antigen ME491, the leukocyte cell surface antigen CD37, and the Sm23 antigen of the parasitic helminth Schistosoma mansoni.
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Presence of Wilms' tumor gene (wt1) transcripts and the WT1 nuclear protein in the majority of human acute leukemias.
TLDR
Its expression in the majority of human acute leukemias but not in normal mononuclear blood cells and normal CD34+ hematopoietic progenitors qualifies the wt1 gene transcript as a 'pan-acute leukemic' marker probably useful in monitoring minimal residual disease after chemotherapy and in detecting leukeMIC blast cells in purged or unpurged hematopolietic stem cell preparations intended to be used for autologous bone marrow transplantation.
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Mutant BRAF and MEK inhibitors regulate the tumor immune microenvironment via pyroptosis.
TLDR
It is shown that BRAFi + MEKi caused durable melanoma regression in an immune-mediated manner and implicate BRAFi+MEKi-induced pyroptosis in anti-tumor immune responses and highlight new therapeutic strategies for resistant melanoma.
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Specific sequences in p120ctn determine subcellular distribution of its multiple isoforms involved in cellular adhesion of normal and malignant epithelial cells.
TLDR
Analysis of the distribution of various p120ctn isoforms and the consequences of their expression in cultured cells of epidermal origin revealed that melanocytes and melanoma cells primarily express the long isoform 1A, whereas keratinocytes express shorter isoforms, especially 3A, which localize to cell-cell adhesion junctions in a calcium-dependent manner.
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