Diverse taxa of cyanobacteria produce beta-N-methylamino-L-alanine, a neurotoxic amino acid.
- P. Cox, S. Banack, B. Bergman
- Biology, Environmental ScienceProceedings of the National Academy of Sciences…
- 5 April 2005
It is reported here that a single neurotoxin, beta-N-methylamino-L-alanine, may be produced by all known groups of cyanobacteria, including cyanobacterial symbionts and free-living cyanob bacteria.
Transfer of a cyanobacterial neurotoxin within a temperate aquatic ecosystem suggests pathways for human exposure
- Sara Jonasson, J. Eriksson, B. Bergman
- Environmental ScienceProceedings of the National Academy of Sciences
- 3 May 2010
It is demonstrated, based on a recently developed extraction and HPLC-MS/MS method and long-term monitoring of BMAA in cyanobacterial populations of a temperate aquatic ecosystem (Baltic Sea, 2007–2008), that BMAA is biosynthesized by cyanob bacterial genera dominating the massive surface blooms of this water body.
Analytical protocol for identification of BMAA and DAB in biological samples.
A robust and sensitive method for high confidence identification of BMAA after derivatization by 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate (AQC) and applicable for selective BMAA/DAB detection in various biological samples ranging from a prokaryotic cyanobacterium to eukaryotic fish.
Diatoms: A Novel Source for the Neurotoxin BMAA in Aquatic Environments
It is demonstrated that diatoms – eukaryotic organisms – also produce BMAA, and the use of filter and suspension feeders as livestock fodder dramatically increases the risk of human exposure to BMAA-contaminated food.
Erratum: Diverse taxa of cyanobacteria produce β-N-methylamino-L- alanine, a neurotoxic amino acid (Proceedings of the National Academy of Sciences of the United States of America (April 5, 2005)…
BMAA in shellfish from two Portuguese transitional water bodies suggests the marine dinoflagellate Gymnodinium catenatum as a potential BMAA source.
Fingerprinting of Cyanobacteria Based on PCR with Primers Derived from Short and Long Tandemly Repeated Repetitive Sequences
The presence of repeated DNA sequences in the genome of cyanobacteria was used to generate a fingerprint method for symbiotic and free-living isolates, indicating that the technique is useful for clustering of even closely related strains.
Phylogeny of symbiotic cyanobacteria within the genus Nostoc based on 16S rDNA sequence analyses
A phylogenetic analysis of selected symbiotic Nostoc strain sequences and available database 16S rDNA sequences of both symbiotic and free-living cyanobacteria was carried out using maximum likelihood and Bayesian inference techniques, verifying that hormogonia formation is not absent in Anabaena and cannot be used as a criterion to distinguish it from Nostoc.
Biodiversity and seasonal variation of the cyanobacterial assemblage in a rice paddy field in Fujian, China.
BMAA Inhibits Nitrogen Fixation in the Cyanobacterium Nostoc sp. PCC 7120
- L. Berntzon, Sven Erasmie, Narin A. Celepli, J. Eriksson, U. Rasmussen, B. Bergman
- BiologyMarine Drugs
- 1 August 2013
The data show that exogenously applied BMAA rapidly inhibits nitrogenase activity (acetylene reduction assay), even at micromolar concentrations, and that the inhibition was considerably more severe than that induced by combined nitrogen sources and most other amino acids.