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Proton NMR spectroscopy of solvent‐saturable resonances: A new approach to study pH effects in Situ
It is shown that the effect of pH changes can be measured in proton NMR spectra through the pH sensitivity of the signal intensities of metabolite protons exchanging with water. To observe thisExpand
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Functional MRI using sensitivity-encoded echo planar imaging (SENSE-EPI)
We investigate the potential of sensitivity-encoded single-shot EPI (SENSE-EPI) for functional MRI, five imaging protocols at different SENSE reduction factors (R) and matrix sizes. Expand
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Combined 1H and 31P spectroscopy provides new insights into the pathobiochemistry of brain damage in multiple sclerosis
1H MRSI has evolved as an important tool to study the onset and progression of brain damage in multiple sclerosis. Abnormal increases in total creatine, total choline and myoinositol have been notedExpand
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Phosphate accumulation and the occurrence of polyphosphates and cyclic 2,3-diphosphoglycerate in Methanosarcina frisia
Methanosarcina frisia accumulates phosphate up to 14% of its dry weight. The phosphate is stored as long-chain polyphosphates as shown by 31P-NMR investigations. Further results show that theExpand
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Characterization of a major permeability barrier in the zebrafish embryo.
Fish embryos represent a class of multicompartmental biological systems that have not been successfully cryopreserved, primarily because of the lack of understanding of how water and cryoprotectantsExpand
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Magnetic resonance microscopy and spectroscopy reveal kinetics of cryoprotectant permeation in a multicompartmental biological system.
Successful cryopreservation of most multicompartmental biological systems has not been achieved. One prerequisite for success is quantitative information on cryoprotectant permeation into and amongstExpand
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Intracellular volume and apparent diffusion constants of perfused cancer cell cultures, as measured by NMR
Diffusion NMR spectroscopy was used to study intracellular volume and apparent water diffusion constants in different cell lines (DU145, human prostate cancer; AT3, rat prostate cancer; MCF‐7, humanExpand
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Two‐compartment model for determination of glycolytic rates of solid tumors by in vivo 13C NMR spectroscopy
Carbon‐13 NMR spectroscopy of 13C enriched substrates is useful for non‐invasively determining metabolic fluxes of cells and tissues. Our study demonstrates that for RIF‐1 tumor cells, examined underExpand
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Real‐time measurements of cellular oxygen consumption, pH, and energy metabolism using nuclear magnetic resonance spectroscopy
Changes in molecular expression or apoptotic behavior, induced by malignant transformation or anticancer treatment, are frequently reflected in cellular metabolism and oxygen consumption. A techniqueExpand
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Imaging prostate cancer invasion with multi-nuclear magnetic resonance methods: the Metabolic Boyden Chamber.
The physiological milieu within solid tumors can influence invasion and metastasis. To determine the impact of the physiological environment and cellular metabolism on cancer cell invasion, it isExpand
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