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Impact of Comorbidities on Mortality in Patients with Idiopathic Pulmonary Fibrosis
A predictive tool for highly prevalent comorbidities, termed IPF COMorbidome, is established which demonstrates a new relationship of IPF and comor bidities, while others such as GERD may inherit a more favourable effect.
Role of c‐jun N‐terminal kinase in the induced release of GM‐CSF, RANTES and IL‐8 from human airway smooth muscle cells
- U. Oltmanns, R. Issa, M. Sukkar, M. John, K. Chung
- Biology, ChemistryBritish journal of pharmacology
- 1 July 2003
Human airway smooth muscle cells (HASMC) contribute to airway inflammation in asthma by virtue of their capacity to produce several inflammatory mediators including IL‐8, GM‐CSF and RANTES, and JNK activation is involved in TNFα‐ and IL‐1β‐induced GM‐ CSF, RantES and IL-8 production from HASMC.
Treatment and outcome of lung cancer in idiopathic interstitial pneumonias.
- M. Kreuter, Svenja Ehlers-Tenenbaum, A. Warth
- MedicineSarcoidosis, vasculitis, and diffuse lung…
- 5 January 2015
LC is a frequent comorbidity in IIP, with a higher incidence and reduced survival in IPF compared to other IIPs, and interdisciplinary evaluation of therapeutic options in IIPs patients diagnosed with LC is mandatory.
Cigarette smoke induces IL-8, but inhibits eotaxin and RANTES release from airway smooth muscle
- U. Oltmanns, K. Chung, M. Walters, M. John, J. Mitchell
- Biology, MedicineRespiratory research
- 19 July 2005
Inhibition of eotaxin and RANTES by cigarette smoke is consistent with the predominant neutrophilic but not eosinophilic inflammation found in COPD.
Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration for the Diagnosis of Intrathoracic Lymphadenopathy in Patients with Extrathoracic Malignancy: A Multicenter Study
Because of the high prevalence of alternative diagnoses, pathological evaluation is important in patients with extrathoracic malignancy and suspected mediastinal or hilar lymph node metastases, and EBUS-TBNA is a safe and sensitive technique and may be considered a first-line investigation in these patients.
Induction of human airway smooth muscle apoptosis by neutrophils and neutrophil elastase.
- U. Oltmanns, M. Sukkar, S. Xie, M. John, K. Chung
- Biology, MedicineAmerican journal of respiratory cell and…
- 14 January 2005
The local release of proteases from neutrophils present in airway smooth muscle cells may lead to HASMC apoptosis as a result of matrix degradation and loss of cell attachment, which may limit pathologic changes such as ASMC hyperplasia and extracellular matrix deposition seen inAirway remodeling.
Regulation of TGF-beta 1-induced connective tissue growth factor expression in airway smooth muscle cells.
- S. Xie, M. Sukkar, R. Issa, U. Oltmanns, A. Nicholson, K. Chung
- BiologyAmerican journal of physiology. Lung cellular and…
TGF-beta 1-stimulated CTGF expression is mediated by mechanisms involving ERK and JNK pathways and is downregulated by IL-4 and IL-13 through modulation of Smad and ERK signals.
Fractalkine/CX3CL1 production by human airway smooth muscle cells: induction by IFN-gamma and TNF-alpha and regulation by TGF-beta and corticosteroids.
- M. Sukkar, R. Issa, S. Xie, U. Oltmanns, R. Newton, K. Chung
- Biology, MedicineAmerican journal of physiology. Lung cellular and…
FKN production by human ASMC in vitro is regulated by inflammatory and anti-inflammatory factors, indicating that JNK is not involved in TGF-beta- or dexamethasone-mediated regulation of FKN production.
Diagnosis of Pulmonary Embolism: Conventional Ventilation/Perfusion SPECT Is Superior to the Combination of Perfusion SPECT and Nonenhanced CT
- Karin Palmowski, U. Oltmanns, M. Kreuter, F. Mottaghy, M. Palmowski, F. Behrendt
- 30 August 2014
It is demonstrated that a nonenhanced CT scan in a novel hybrid imaging system cannot replace V-SPECT in the scintigraphy-based diagnosis of PE and V- SPECT increases specificity and reduces the number of false-positive results when compared to ‘perfusion-only' SPECT/CT.
Pirfenidone in Idiopathic Pulmonary Fibrosis: Real-Life Experience from a German Tertiary Referral Center for Interstitial Lung Diseases
In this heterogeneous patient group, a nonsignificant effect of pirfenidone treatment on pulmonary function was seen, underlining the need for more data on patient selection criteria and efficacy of pirenidone, particularly in patients with coexistent emphysema and concomitant NAC/CCS treatment.