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CXCR7 Functions as a Scavenger for CXCL12 and CXCL11
Background CXCR7 (RDC1), the recently discovered second receptor for CXCL12, is phylogenetically closely related to chemokine receptors, but fails to couple to G-proteins and to induce typical… Expand
Monocyte chemoattractant protein–1 increases microglial infiltration and aggressiveness of gliomas
Macrophages are thought to represent a first line of defense in anti‐tumor immunity. Despite infiltration by microglial cells, however, malignant gliomas are still highly aggressive tumors. We here… Expand
Cognitive interpersonal maintenance model of eating disorders: intervention for carers.
- E. Goddard, P. Macdonald, +4 authors J. Treasure
- Medicine, Psychology
- The British journal of psychiatry : the journal…
- 1 September 2011
BACKGROUND Carers of people with eating disorders report high levels of distress. In addition, carers' responses to the illness may perpetuate eating disorder symptoms. A cognitive interpersonal… Expand
MICA/NKG2D-mediated immunogene therapy of experimental gliomas.
The failure of conventional cancer therapy renders glioblastoma an attractive target for immunotherapy. Tumor cells expressing ligands of the activating immunoreceptor NKG2D stimulate tumor immunity… Expand
Cognitive remediation and emotion skills training for anorexia nervosa: an observational study using neuropsychological outcomes.
- H. Davies, J. Fox, U. Naumann, J. Treasure, U. Schmidt, K. Tchanturia
- Psychology, Medicine
- European eating disorders review : the journal of…
- 1 May 2012
OBJECTIVE This study aims to evaluate a novel and brief skills-based therapy for in-patients with anorexia nervosa, which addressed 'cold' and 'hot' cognition. METHOD Eighty one adults with… Expand
APO2 ligand: a novel lethal weapon against malignant glioma?
APO2L (TRAIL) is a novel CD95L (Fas/APO‐1‐L) homologous cytotoxic cytokine that interacts with various receptors which transmit (DR4, DR5) or inhibit (DcR1, DcR2) an apoptotic signal. Here, we report… Expand
Processing of Immunosuppressive Pro-TGF-β1,2 by Human Glioblastoma Cells Involves Cytoplasmic and Secreted Furin-Like Proteases1
- J. Leitlein, S. Aulwurm, +5 authors M. Platten
- Medicine, Biology
- The Journal of Immunology
- 15 June 2001
TGF-β is a putative mediator of immunosuppression associated with malignant glioma and other types of cancer. Subtilisin-like proprotein convertases such as furin are thought to mediate TGF-β… Expand
CP-31398, a novel p53-stabilizing agent, induces p53-dependent and p53-independent glioma cell death
- J. Wischhusen, U. Naumann, H. Ohgaki, F. Rastinejad, M. Weller
- Biology, Medicine
- 13 November 2003
CP-31398 is a prototype small molecule that stabilizes the active conformation of p53 and promotes p53 activity in cancer cell lines with mutant or wild-type p53. Here, we report that CP-31398… Expand
A novel p53 rescue compound induces p53-dependent growth arrest and sensitises glioma cells to Apo2L/TRAIL-induced apoptosis
- L. Weinmann, J. Wischhusen, +4 authors M. Weller
- Biology, Medicine
- Cell Death and Differentiation
- 1 April 2008
Reactivation of mutant p53 in tumours is a promising strategy for cancer therapy. Here we characterise the novel p53 rescue compound P53R3 that restores sequence-specific DNA binding of the… Expand
TP53 promoter methylation in human gliomas
Methylation of the promoter region of tumor suppressor genes may be associated with transcriptional silencing and tumor progression. The 5′ region of the TP53 gene does not contain a CpG island, but… Expand