• Publications
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Mucoid Pseudomonas aeruginosa, TNF-alpha, and IL-1beta, but not IL-6, induce human beta-defensin-2 in respiratory epithelia.
TLDR
Human beta-defensin-2 represents a major inducible antimicrobial factor released by airway epithelial cells either on contact with mucoid PA or by endogenously produced primary cytokines, which might be important in lung infections caused by mucoide PA, including those seen in patients with CF. Expand
Mucoid Pseudomonas aeruginosa, TNF- α , and IL-1 β , but Not IL-6, Induce Human β -Defensin-2 in Respiratory Epithelia
TLDR
This work purified antimicrobial activity from supernatants of the A549 lung epithelial cell line, previously stimulated with PA bacteria, by subsequent high performance liquid chromatography and revealed it to be identical with human beta-defensin-2 (hBD-2). Expand
Enhanced expression and secretion of antimicrobial peptides in atopic dermatitis and after superficial skin injury.
TLDR
A disturbed skin barrier may trigger AMP induction in AD and psoriasis, and the functional role of AMP in AD, especially with regard to the control of S. aureus colonization, needs further analysis. Expand
The antimicrobial protein psoriasin (S100A7) is upregulated in atopic dermatitis and after experimental skin barrier disruption.
TLDR
The functional role of psoriasin in AD patients is investigated to indicate that the antimicrobial response in AD is not generally impaired, but greatly differs according to the type of AMP produced by the skin. Expand
Differential gene induction of human beta-defensins (hBD-1, -2, -3, and -4) in keratinocytes is inhibited by retinoic acid.
TLDR
RA is a potent inhibitor of beta-defensin induction in keratinocytes and might downregulate the inducible innate chemical defense system of human skin. Expand
Neutrophil serine proteases: potential key regulators of cell signalling during inflammation
TLDR
Neutrophil serine proteases are potential key regulators of cell signalling during inflammation and should be considered as a next-generation target for drug discovery. Expand
Myeloid differentiation factor 88‐dependent signalling controls bacterial growth during colonization and systemic pneumococcal disease in mice
  • B. Albiger, A. Sandgren, +6 authors Birgitta Henriques Normark
  • Biology, Medicine
  • Cellular microbiology
  • 1 November 2005
TLDR
It is demonstrated that both local and systemic inflammatory response to S. pneumoniae depends on the presence of MyD88 to clear bacterial colonization of the upper respiratory tract and the inability to lower the serum iron concentration in response to infection. Expand
Secreted enteric antimicrobial activity localises to the mucus surface layer
TLDR
Findings show that secreted antimicrobial peptides are retained by the surface-overlaying mucus and thereby provide a combined physical and antibacterial barrier to prevent bacterial attachment and invasion. Expand
High-density genotyping study identifies four new susceptibility loci for atopic dermatitis
TLDR
The number of atopic dermatitis risk loci reported in individuals of European ancestry is increased to 11, and it is estimated that these susceptibility loci together account for 14.4% of the heritability for atopy dermatitis. Expand
Kallikreins - The melting pot of activity and function.
TLDR
The current state of knowledge regarding the physiological functions of KLKs in major human organs is presented and recent discoveries pertinent to the involvement of kallikreins in cell signaling and in viral infections are outlined. Expand
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