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Detection of genotoxic effects in human gastric and nasal mucosa cells isolated from biopsy samples
The data imply that lindane will pose a health risk to humans by inhalation but not by ingestion, and can be interpreted according to a parallelogram approach. Expand
Induction of DNA damage by risk factors of colon cancer in human colon cells derived from biopsies.
Those compounds chosen as representatives of endogenously formed risk factors (MNNG, H2O2, LCA) have a higher toxic and/or genotoxic potency in human colon tissue than in rat colon. Expand
Human gastric acid secretion following repeated doses of AG‐1749
The effect of increasing doses (15 mg, 30 mg and 60 mg) of the substituted benzimidazole, AG‐1749, on gastric acid secretion and fasting serum gastrin concentration has been studied after repeatedExpand
Dose-range finding study with the proton pump inhibitor pantoprazole in acute duodenal ulcer patients.
Pantoprazole provides fast healing of acute duodenal ulcer as well as rapid improvement of ulcer symptoms in patients with peptic ulcer disease. Expand
[Ranitidine ameliorates acemetacin and indomethacin-induced changes of the gastroduodenal mucosa, without modifying the pharmacokinetic behavior of both antirheumatic drugs].
The data suggest that 300 mg ranitidine at night improves the gastroduodenal tolerability of both indomethacin and acemetacin without affecting main pharmacokinetic parameters of both antirheumatics. Expand
Comparison of the gastroduodenal tolerance of tenoxicam and diclofenac Na
Tenoxicam was significantly better tolerated at the end of the 14 day dosing period and the two treatment groups had comparable scores at the base-line and post study assessments. Expand
Ranitidine in the Therapy of NSAID-Induced Gastroduodenal Lesions: Results of a Randomized, Placebo-Controlled, Double-Blind Study in Patients with Rheumatic Diseases
Forty-six patients with rheumatic diseases suffering from dyspepsia and endo-scopically proven gastroduodenal lesions entered a double-blind placebo-controlled study with 150 mg ranitidine twiceExpand
[Nizatidine in therapy and prevention of non-steroidal anti-rheumatic drug-induced ulcers in rheumatic patients].
There was a tendency for higher healing rates in case of gastric ulcers after 4 weeks following the higher dose of nizatidine and the same holds with respect to improvement of clinical symptoms such as epigastric pain, heartburn etc. Expand
An alprostadil analogue and human gastric secretion. A double-blind placebo-controlled study of the effects of a capsule and tablet formulation.
Administration of mexiprostil resulted in a significant inhibition of basal gastric acid secretion, at both doses and formulations, compared to placebo and there was no significant difference between the effects of both formulations ofmexip Frostil on any pharmacodynamic parameter. Expand
[High-dose ranitidine protects stomach and duodenum completely against piroxicam. An endoscopic double-blind pilot study].
It is suggested that profound acid inhibition--achieved by doubling the usual dose--afforded complete protection of human stomach and duodenum against piroxicam. Expand