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Immunoproteasomes Preserve Protein Homeostasis upon Interferon-Induced Oxidative Stress
Interferon (IFN)-induced immunoproteasomes (i-proteasomes) have been associated with improved processing of major histocompatibility complex (MHC) class I antigens. Here, we show that i-proteasomesExpand
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Comparative resistance of the 20S and 26S proteasome to oxidative stress.
Oxidatively modified ferritin is selectively recognized and degraded by the 20S proteasome. Concentrations of hydrogen peroxide (H2O2) higher than 10 micromol/mg of protein are able to preventExpand
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Interferon‐γ, the functional plasticity of the ubiquitin–proteasome system, and MHC class I antigen processing
Summary:  The proteasome system is a central component of a cascade of proteolytic processing steps required to generate antigenic peptides presented at the cell surface to cytotoxic T lymphocytes byExpand
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Peptide antigen production by the proteasome: complexity provides efficiency.
Abstract Proteasomes have recently been shown to be central to the production of antigenic peptides that can bind to major histocompatibility complex class I molecules. Here, Marcus Groettrup andExpand
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Incorporation of major histocompatibility complex--encoded subunits LMP2 and LMP7 changes the quality of the 20S proteasome polypeptide processing products independent of interferon-gamma.
The 20S proteasome is the enzyme complex responsible for the processing of antigens bound by major histocompatibility complex class I molecules. The role of the interferon-gamma (IFN-gamma)-inducibleExpand
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Impairment of Immunoproteasome Function by β5i/LMP7 Subunit Deficiency Results in Severe Enterovirus Myocarditis
Proteasomes recognize and degrade poly-ubiquitinylated proteins. In infectious disease, cells activated by interferons (IFNs) express three unique catalytic subunits β1i/LMP2, β2i/MECL-1 and β5i/LMP7Expand
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Circulating proteasomes are markers of cell damage and immunologic activity in autoimmune diseases.
OBJECTIVE The 20S proteasome plays a leading immunologic role in the cytosolic generation of MHC class I restricted antigens, and it represents an abundant antigen in several autoimmune diseases. ToExpand
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Ongoing coxsackievirus myocarditis is associated with increased formation and activity of myocardial immunoproteasomes.
A growing body of evidence indicates that viral infections of the heart contribute to ongoing myocarditis and dilated cardiomyopathy. Murine models of coxsackievirus B3 (CVB3)-induced myocarditisExpand
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Circulating proteasome levels are an independent prognostic factor for survival in multiple myeloma.
The proteasome is a proteolytic complex for intracellular degradation of ubiquitinated proteins which are involved in cell-cycle regulation and apoptosis. A constitutively increased proteasomeExpand
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The components of the proteasome system and their role in MHC class I antigen processing.
By generating peptides from intracellular antigens which are then presented to T cells, the ubiquitin/26S proteasome system plays a central role in the cellular immune response. The proteolyticExpand
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