• Publications
  • Influence
Purinergic signalling: From normal behaviour to pathological brain function
Purinergic neurotransmission, involving release of ATP as an efferent neurotransmitter was first proposed in 1972. Later, ATP was recognised as a cotransmitter in peripheral nerves and more recentlyExpand
  • 316
  • 23
P2 receptors and neuronal injury
Extracellular adenosine 5′-triphosphate (ATP) was proposed to be an activity-dependent signaling molecule that regulates glia–glia and glia–neuron communications. ATP is a neurotransmitter of its ownExpand
  • 154
  • 17
Basal and feeding-evoked dopamine release in the rat nucleus accumbens is depressed by leptin.
The involvement of the satiety-controlling hormone leptin in the modulation of the reward-associated dopamine release was investigated by monitoring the extracellular dopamine concentration inExpand
  • 163
  • 10
Flavanones That Selectively Inhibit TRPM3 Attenuate Thermal Nociception In Vivo
Transient receptor potential melastatin 3 (TRPM3) is a calcium-permeable nonselective cation channel that is expressed in a subset of dorsal root (DRG) and trigeminal ganglia sensory neurons. TRPM3Expand
  • 55
  • 7
  • PDF
Extracellular Ca2+ is a danger signal activating the NLRP3 inflammasome through G protein-coupled calcium sensing receptors
Activation of the NLRP3 inflammasome enables monocytes and macrophages to release high levels of interleukin-1β during inflammatory responses. Concentrations of extracellular calcium can increase atExpand
  • 259
  • 6
P2Y receptor expression on astrocytes in the nucleus accumbens of rats
The expression of purinoceptor (P2)Y-subtypes on astrocytes in vivo under physiological conditions and after stab wound injury was investigated. Reverse transcriptase-polymerase chain reaction withExpand
  • 95
  • 6
P2X receptor expression on astrocytes in the nucleus accumbens of rats
Astrocytes express a variety of neurotransmitter receptors which render them capable of responding to extracellular stimuli, like ATP. Release of ATP, e.g. after brain injury, may initiate reactiveExpand
  • 94
  • 6
Changes in purinergic signaling after cerebral injury – involvement of glutamatergic mechanisms?
Extracellular purines act as neuromodulators on transmitter release and may exert toxic effects at higher concentrations. In microdialysis studies, endogenous ATP facilitated the extracellularExpand
  • 60
  • 6
Primidone inhibits TRPM3 and attenuates thermal nociception in vivo
Abstract The melastatin-related transient receptor potential (TRP) channel TRPM3 is a nonselective cation channel expressed in nociceptive neurons and activated by heat. Because TRPM3-deficient miceExpand
  • 25
  • 6
Enhanced food intake after stimulation of hypothalamic P2Y1 receptors in rats: modulation of feeding behaviour by extracellular nucleotides
The present study was aimed to clarify the role of purinergic signalling in the regulation of ingestion behaviour. The ATP/ADP analogues 2‐methylthioATP (2‐MeSATP) and adenosineExpand
  • 46
  • 5