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The genomes of four tapeworm species reveal adaptations to parasitism
Tapeworms (Cestoda) cause neglected diseases that can be fatal and are difficult to treat, owing to inefficient drugs. Here we present an analysis of tapeworm genome sequences using theExpand
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The unique stem cell system of the immortal larva of the human parasite Echinococcus multilocularis
BackgroundIt is believed that in tapeworms a separate population of undifferentiated cells, the germinative cells, is the only source of cell proliferation throughout the life cycle (similar to theExpand
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How might flukes and tapeworms maintain genome integrity without a canonical piRNA pathway?
Surveillance by RNA interference is central to controlling the mobilization of transposable elements (TEs). In stem cells, Piwi argonaute (Ago) proteins and associated proteins repress mobilizationExpand
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Comparative analysis of Wnt expression identifies a highly conserved developmental transition in flatworms
BackgroundEarly developmental patterns of flatworms are extremely diverse and difficult to compare between distant groups. In parasitic flatworms, such as tapeworms, this is confounded by highlyExpand
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Hox Genes in the Parasitic Platyhelminthes Mesocestoides corti, Echinococcus multilocularis, and Schistosoma mansoni: Evidence for a Reduced Hox Complement
Little is known about the Hox gene complement in parasitic platyhelminthes (Neodermata). With the aim of identifying Hox genes in this group we performed two independent strategies: we performed aExpand
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Precursors of neuropeptides and peptide hormones in the genomes of tardigrades.
  • U. Koziol
  • Medicine, Biology
  • General and comparative endocrinology
  • 1 October 2018
Tardigrades are a key group for understanding the evolution of the Ecdysozoa, a large clade of molting animals that also includes arthropods and nematodes. However, little is known about most aspectsExpand
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Echinococcus-Host Interactions at Cellular and Molecular Levels.
The potentially lethal zoonotic diseases alveolar and cystic echinococcosis are caused by the metacestode larval stages of the tapeworms Echinococcus multilocularis and Echinococcus granulosus,Expand
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De novo discovery of neuropeptides in the genomes of parasitic flatworms using a novel comparative approach.
Neuropeptide mediated signalling is an ancient mechanism found in almost all animals and has been proposed as a promising target for the development of novel drugs against helminths. However,Expand
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Host insulin stimulates Echinococcus multilocularis insulin signalling pathways and larval development
BackgroundThe metacestode of the tapeworm Echinococcus multilocularis is the causative agent of alveolar echinococcosis, a lethal zoonosis. Infections are initiated through establishment of parasiteExpand
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On the importance of targeting parasite stem cells in anti-echinococcosis drug development
The life-threatening diseases alveolar and cystic echinococcoses are caused by larvae of the tapeworms Echinococcus multilocularis and E. granulosus, respectively. In both cases, intermediate hosts,Expand
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