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T-lymphocyte Infiltration in Visceral Adipose Tissue: A Primary Event in Adipose Tissue Inflammation and the Development of Obesity-Mediated Insulin Resistance
Proinflammatory T-lymphocytes are present in visceral adipose tissue and may contribute to local inflammatory cell activation before the appearance of macrophages, suggesting that these cells could play an important role in the initiation and perpetuation of adipOSE tissue inflammation as well as the development of IR.
Posttranslational modification of MDM2.
This review summarizes the current knowledge of the role of posttranslational modifications of MDM2 and their functional relevance and governs its subcellular localization.
p53 is linked directly to homologous recombination processes via RAD51/RecA protein interaction.
It is reported that p53 physically interacts with key factors of homologous recombination: the human RAD51 protein and its prokaryotic homologue RecA and these observations suggest that functional wild‐type p53 may select directly the appropriate pathway for DNA repair and control the extent and timing of the production of genetic variation via homologously recombination.
Independent expression of the transforming amino‐terminal domain of SV40 large I antigen from an alternatively spliced third SV40 early mRNA.
The expression of the transforming amino‐terminal domain of large T as an independent 17kT protein might provide a means for individually regulating the various functions associated with this domain.
IC261, a specific inhibitor of the protein kinases casein kinase 1-delta and -epsilon, triggers the mitotic checkpoint and induces p53-dependent postmitotic effects
Evidence is provided that 3-[(2,4,6-trimethoxyphenyl)methylidenyl]-indolin-2-one (IC261), a novel inhibitor of CK1δ and CK1ε, triggers the mitotic checkpoint control and Immunfluorescence images show that at low concentrations IC261 leads to centrosome amplification causing multipolar mitosis.
Obesity-induced overexpression of miR-802 impairs glucose metabolism through silencing of Hnf1b
A critical role is defined for deregulated expression of miR-802 in the development of obesity-associated impairment of glucose metabolism through targeting of Hnf1b, and Hn f1b is assigned an unexpected role in the control of hepatic insulin sensitivity.
De novo lipogenesis in human fat and liver is linked to ChREBP-β and metabolic health.
It is shown that lipogenic enzymes and the glucose transporter-4 are markedly decreased in white adipose tissue of insulin-resistant obese individuals compared with non-obese controls and are likely regulated by glucose-dependent carbohydrate-responsive element-binding protein activation.
The CK1 Family: Contribution to Cellular Stress Response and Its Role in Carcinogenesis
Members of the highly conserved and ubiquitously expressed pleiotropic CK1 family play major regulatory roles in many cellular processes including DNA-processing and repair, proliferation,
p53 is phosphorylated in vitro and in vivo by the delta and epsilon isoforms of casein kinase 1 and enhances the level of casein kinase 1 delta in response to topoisomerase-directed drugs
Evidence is presented that the delta and epsilon isoforms of casein kinase 1 (CK1δ and CK1ε) show identical features to p53NK and can phosphorylate p53 both in vitro and in vivo, and additionally that there may be a regulatory feedback loop involving p53 and CK 1δ.