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Ca2+ Signaling Tools Acquired from Prostasomes Are Required for Progesterone-Induced Sperm Motility
It is shown that a long-lasting Ca2+ signal required for sperm motility in response to progesterone depends on their pH-dependent fusion with prostasomes, which are small vesicles secreted by the prostate.
Tyrosine residues in bovine phospholipase C-gamma phosphorylated by the epidermal growth factor receptor in vitro.
It is proposed that the phosphorylation of PLC-gamma by EGF receptor kinase alters its interaction with putative inhibitory proteins and leads to its activation.
Doxorubicin-induced reactive oxygen species generation and intracellular Ca2+increase are reciprocally modulated in rat cardiomyocytes
- Seon-Young Kim, Sang-Jin Kim, +4 authors U. Kim
- Biology, MedicineExperimental & Molecular Medicine
- 31 October 2006
Doxorubicin-mediated ROS opens ryanodine receptor, resulting in an increase in Ca2+i and that the increased [Ca2+]i induces ROS production, suggesting that DOX/ROS-induced increase of [Ca 2+] i plays a critical role in damage of cardiomyocytes.
Two genetic variants of CD38 in subjects with autism spectrum disorder and controls
The immunohistochemical expression of CD38 in the hypothalamus of post-mortem brains of non-ASD subjects is examined and it is found that CD38 was colocalized with OT in secretory neurons.
Generation of Nicotinic Acid Adenine Dinucleotide Phosphate and Cyclic ADP-Ribose by Glucagon-Like Peptide-1 Evokes Ca2+ Signal That Is Essential for Insulin Secretion in Mouse Pancreatic Islets
The findings demonstrate that the GLP-1–mediated Ca2+ signal for insulin secretion in pancreatic β-cells is a cooperative action of NAADP and cyclic ADPR spatiotemporally formed by multiple enzymes.
Feedback regulation of phospholipase C-beta by protein kinase C.
- S. Ryu, U. Kim, +4 authors S. Rhee
- Medicine, BiologyThe Journal of biological chemistry
- 15 October 1990
It is proposed that rather than having a direct effect on enzyme activity, the phosphorylation of PLC-beta by PKC may alter its interaction with a putative guanine nucleotide-binding regulatory protein and thereby prevent its activation.
Peroxisome proliferator activated receptor-gamma modulates reactive oxygen species generation and activation of nuclear factor-kappaB and hypoxia-inducible factor 1alpha in allergic airway disease of…
- K. S. Lee, So Ri Kim, +6 authors Yong Chul Lee
- MedicineThe Journal of allergy and clinical immunology
The results indicate that the effects of PPARgamma are mediated by the modulation of ROS generation and activation of redox-sensitive transcription factor nuclear factor-kappaB and HIF-1alpha in allergic airway disease of mice.
Peroxisome proliferator activated receptor-γ modulates reactive oxygen species generation and activation of nuclear factor-κB and hypoxia-inducible factor 1α in allergic airway disease of mice
The results indicate that the effects of PPARγ are mediated by the modulation of ROS generation and activation of redox-sensitive transcription factor nuclear factor-κB and HIF-1α in allergic airway disease of mice.
Hemolytic mechanism of cytolysin produced from V. vulnificus.
The results suggest that the cytolysin lyses erythrocytes due to the formation of small pores on ERYthrocyte membrane by cholesterol-mediated oligomerization of the cy tolysin.
Extracellular NAD is a regulator for FcgammaR-mediated phagocytosis in murine macrophages.
- Eun-Kyung Song, Young-Rae Lee, +9 authors Myung-Kwan Han
- Biology, MedicineBiochemical and biophysical research…
- 29 February 2008
It is shown that extracellular NAD enhances FcGamma receptor (FcgammaR)-mediated phagocytosis in J774A.1 macrophage via the conversion into cyclic ADp-ribose (cADPR), a potent calcium mobilizer, by CD38, an ADP-ribosyl cyclase.