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Heme oxygenase-1-mediated anti-inflammatory effects of tussilagonone on macrophages and 12-O-tetradecanoylphorbol-13-acetate-induced skin inflammation in mice.
TGN is a potent therapeutic candidate for targeting the crosstalk between Nrf2/HO-1 and the NF-κB signaling pathway in the prevention or treatment of inflammation-associated diseases. Expand
National Cancer Institute (NCI) Program for Natural Products Discovery: Rapid Isolation and Identification of Biologically Active Natural Products from the NCI Prefractionated Library
Overall, the rapid second-stage purification conserves extract mass, requires much less chemist time, and introduces knowledge of structure early in the isolation workflow. Expand
Identification of cytoprotective constituents of the flower buds of Tussilago farfara against glucose oxidase-induced oxidative stress in mouse fibroblast NIH3T3 cells and human keratinocyte HaCaT
A new cytoprotective compound, 1-[(4S)-3,4-dihydro-4-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl]-ethanone (1) was isolated from the flower buds of Tussilago farfara L. (Compositae), together with eight known compounds, 2–4 were found in this plant for the first time. Expand
A new secoiridoid glycoside from the fruits of Cornus officinalis (Cornaceae)
Abstract A new secoiridoid glycoside, 7β-O-dimethyl butanedioate morroniside (1) was isolated from the fruits of Cornus officinalis (Cornaceae) along with the known compound, caffeoyltartaric acidExpand
Identification of a New Fatty Acid from the Seeds of Coix lachryma-jobi var. ma-yuen
College of Pharmacy, Seoul National University, Seoul 151-742, KoreaReceived December 5, 2012, Accepted January 17, 2013Key Words : Coix lachryma-jobi L. var. ma-yuen Stapf., Gramineae, Fatty acidTheExpand
Dehydrocostus lactone, a sesquiterpene from Saussurea lappa Clarke, suppresses allergic airway inflammation by binding to dimerized translationally controlled tumor protein.
DCL's therapeutic potential in allergic airway inflammation is based on its anti-inflammatory activity of suppressing the function of dTCTP, a natural sesquiterpene present in rhizome of Saussurea lappa Clarke. Expand
Peroxynitrite-Scavenging Glycosides from the Stem Bark of Catalpa ovata.
Ten new glycosides were isolated from the stem bark of Catalpa ovata along with 19 known compounds, and 12 compounds showed potent activity, with IC50 values in the range 0.14-2.2 μM. Expand
Elucidation of Spirodactylone, a Polycyclic Alkaloid from the Sponge Dactylia sp., and Nonenzymatic Generation from the Co-metabolite Denigrin B.
Oxidative cyclization of denigrin B (2), an aryl-substituted 2-oxo-pyrroline derivative that was also isolated from the sponge extract, provided material identical to spirodactylone, which confirmed the assigned structure and provides insight into the probable biogenesis of 1. Expand
Tussilagonone-induced Nrf2 pathway activation protects HepG2 cells from oxidative injury.
Data indicate that tussilagonone attenuates t-BHP-induced ROS and activates quinone reductase activity via Nrf2 pathway activation and target gene expression, and thereby acts as an antioxidant that protects HepG2 cells from oxidative stress and associated damage. Expand
Chemical Constituents of the Radices of Angelica tenuissima
Angelica tenuissima Nakai (=Ligusticum tenuissimum Kitagawa, Umbelliferae) is widely used to treat headache, diarrhea, epilepsy, and rheumatic arthralgias in oriental traditional medicine [1]. ThereExpand