• Publications
  • Influence
Evidence of oxidative stress in the pathogenesis of fuchs endothelial corneal dystrophy.
Fuchs endothelial corneal dystrophy (FECD) is a progressive, blinding disease characterized by corneal endothelial (CE) cell apoptosis. Corneal transplantation is the only measure currently availableExpand
  • 168
  • 15
Mutations in LOXHD1, a recessive-deafness locus, cause dominant late-onset Fuchs corneal dystrophy.
Fuchs corneal dystrophy (FCD) is a genetic disorder of the corneal endothelium and is the most common cause of corneal transplantation in the United States. Previously, we mapped a late-onset FCDExpand
  • 117
  • 9
Inflammation and the nervous system: the connection in the cornea in patients with infectious keratitis.
PURPOSE To study the density and morphologic characteristics of epithelial dendritic cells, as correlated to subbasal corneal nerve alterations in acute infectious keratitis (IK) by in vivo confocalExpand
  • 129
  • 7
  • PDF
Topical bevacizumab in the treatment of corneal neovascularization: results of a prospective, open-label, noncomparative study.
OBJECTIVE To study the safety and efficacy of topical bevacizumab in the treatment of corneal neovascularization (NV). DESIGN In a prospective, open-label, noncomparative study, 10 eyes from 10Expand
  • 174
  • 5
  • PDF
Topical interleukin 1 receptor antagonist for treatment of dry eye disease: a randomized clinical trial.
IMPORTANCE The immunopathogenic mechanisms of dry eye disease (DED), one of the most common ophthalmic conditions, is incompletely understood. Data from this prospective, double-masked, randomizedExpand
  • 78
  • 5
Colocalization of increased transforming growth factor-beta-induced protein (TGFBIp) and Clusterin in Fuchs endothelial corneal dystrophy.
PURPOSE To investigate the differential expression of TGFBIp in normal human and Fuchs endothelial corneal dystrophy (FECD) endothelial cell-Descemet's membrane (HCEC-DM) complex, and to asses theExpand
  • 48
  • 5
Fungal Keratitis: Changing Pathogens and Risk Factors
Purpose: To describe changes in demographics and pathogens for fungal keratitis cases diagnosed at the Massachusetts Eye and Ear Infirmary. Methods: Patient demographics, clinical and laboratoryExpand
  • 81
  • 4
UV-A Irradiation Activates Nrf2-Regulated Antioxidant Defense and Induces p53/Caspase3-Dependent Apoptosis in Corneal Endothelial Cells
Purpose To examine whether Nrf2-regulated antioxidant defense and p53 are activated in human corneal endothelial cells (CEnCs) by environmental levels of ultraviolet A (UV-A), a known stimulator ofExpand
  • 34
  • 4
  • PDF
Decreased DJ-1 leads to impaired Nrf2-regulated antioxidant defense and increased UV-A-induced apoptosis in corneal endothelial cells.
PURPOSE To investigate the role of DJ-1 in Nrf2-regulated antioxidant defense in corneal endothelial cells (CECs) at baseline and in response to ultraviolet A (UV-A)-induced oxidative stress. Expand
  • 44
  • 4
  • PDF
The culture and transplantation of human limbal stem cells
The cornea is the clear front of the eye and its surface is composed of an epithelium. This is renewed by stem cells located at the limbus, which encircles the periphery of the cornea. These limbalExpand
  • 61
  • 4