Author pages are created from data sourced from our academic publisher partnerships and public sources.
Share This Author
Antiinflammatory effects of euclyptol (1.8-cineole) in bronchial asthma: inhibition of arachidonic acid metabolism in human blood monocytes ex vivo.
- U. Juergens, M. Stöber, L. Schmidt-Schilling, T. Kleuver, H. Vetter
- European journal of medical research
- 17 September 1998
Monoterpenes are prescribed to treat chronic obstructive airway disorders mainly because of their familiar secretolytic properties. The aim of this study was to investigate the effect of 1.8-cineole… Expand
Inhibition of cytokine production and arachidonic acid metabolism by eucalyptol (1.8-cineole) in human blood monocytes in vitro.
Cineole (eucalyptol) is the isolated active agent of eucalyptus oil. Traditionally, it is recommended for treating the symptoms of airway diseases exacerbated by infection. We have examined the… Expand
Role of Epac1 in mediating anti-proliferative effects of prostanoid EP2 receptors and cAMP in human lung fibroblasts
- S. Haag, M. Warnken, U. Juergens, K. Racké
- Biology, Medicine
- Naunyn-Schmiedeberg's Archives of Pharmacology
- 22 July 2008
In lung fibroblasts, proliferation is inhibited by activation of EP2 prostanoid receptors which are known to couple to adenylyl cyclase. Beside the classic target of cAMP, protein kinase A (PKA),… Expand
Anti-inflammatory activity of 1.8-cineol (eucalyptol) in bronchial asthma: a double-blind placebo-controlled trial.
- U. Juergens, U. Dethlefsen, G. Steinkamp, A. Gillissen, R. Repges, H. Vetter
- Respiratory medicine
- 1 March 2003
Airway hypersecretion is mediated by increased release of inflammatory mediators and can be improved by inhibition of mediator production. We have recently reported that 1.8-cineol (eucalyptol) which… Expand
Inhibitory activity of 1,8-cineol (eucalyptol) on cytokine production in cultured human lymphocytes and monocytes.
- U. Juergens, Tanja Engelen, K. Racké, M. Stöber, A. Gillissen, H. Vetter
- Pulmonary pharmacology & therapeutics
- 1 October 2004
BACKGROUND The therapeutic value of secretolytic agents in COPD and asthma is still disputed. For this reason, in a preclinical study we aimed to test the potential anti-inflammatory efficacy of… Expand
Control by cholinergic mechanisms.
In the respiratory tract acetylcholine is neurotransmitter in ganglia and postganglionic parasympathetic nerves, but in addition is paracrine mediator released from various non-neuronal cells. Almost… Expand
Muscarinic receptors mediate stimulation of collagen synthesis in human lung fibroblasts
Clinical observations indicate that in chronic obstructive pulmonary disease patients, the long-acting muscarinic antagonist tiotropium delays decline in airway function, suggesting that cholinergic… Expand
Elevation of tissue kallikrein and kinin in the airways of asthmatic subjects after endobronchial allergen challenge.
- S. Christiansen, D. Proud, R. B. Sarnoff, U. Juergens, C. Cochrane, B. Zuraw
- The American review of respiratory disease
- 1 April 1992
Bronchial tissue kallikrein is the major kininogenase activity in the airways of asthmatic subjects. The relationship of IgE-mediated events to its release and/or activation is unknown, however, and… Expand
Muscarinic receptors mediate stimulation of human lung fibroblast proliferation.
- S. Matthiesen, Amit Bahulayan, +5 authors K. Racké
- Biology, Medicine
- American journal of respiratory cell and…
- 10 August 2006
Airway remodeling is a structural alteration associated with chronic inflammatory and obstructive airway diseases, wherein fibroblasts are crucially involved. The present study investigates whether… Expand
Anti-inflammatory properties of the monoterpene 1.8-cineole: current evidence for co-medication in inflammatory airway diseases.
- U. Juergens
- Drug research
- 15 May 2014
1,8-cineole is a natural monoterpene, also known as eucalyptol. It is a major compound of many plant essential oils, mainly extracted from Eucalyptus globulus oil. As an isolated compound,… Expand