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RGD modified polymers: biomaterials for stimulated cell adhesion and beyond.
TLDR
The impacts of RGD peptide surface density, spatial arrangement as well as integrin affinity and selectivity on cell responses like adhesion and migration are discussed.
Multimeric cyclic RGD peptides as potential tools for tumor targeting: solid-phase peptide synthesis and chemoselective oxime ligation.
TLDR
Solid-phase peptide synthesis of multimeric cyclo(-RGDfE-)-peptides is described, which offer the possibility of enhanced integrin targeting due to polyvalency effects, and an aminooxy group for versatile chemoselective oxime ligation.
Two-step methodology for high-yield routine radiohalogenation of peptides: (18)F-labeled RGD and octreotide analogs.
TLDR
Oxime formation between aminooxy-functionalized peptides and an (18)F-labeled aldehyde or ketone was investigated and optimized with respect to peptide conjugation and showed pharmacokinetics suitable for early high-contrast PET imaging, high tumor uptake, and tumor-to-organ ratios that compared well with the corresponding fluoropropionyl analogs.
Mediating specific cell adhesion to low-adhesive diblock copolymers by instant modification with cyclic RGD peptides.
TLDR
A surface modification concept for the covalent anchoring of RGD peptides to reactive diblock copolymers based on monoamine poly(ethylene glycol)-block-poly(D,L-lactic acid) (H(2)N-PEG-PLA) was demonstrated and significantly increased cell numbers and cell spreading on theRGD-modified surfaces mediated by RGD-integrin-interactions.
Photoswitched cell adhesion on surfaces with RGD peptides.
TLDR
The possibility to switch cell adhesion properties by changing the distance and orientation of the RGD peptides to the surface is described and control of adhesion stimulation by irradiation with 366 or 450 nm light is achieved.
TransCon CNP, a Sustained-Release C-Type Natriuretic Peptide Prodrug, a Potentially Safe and Efficacious New Therapeutic Modality for the Treatment of Comorbidities Associated with Fibroblast Growth
TLDR
Preclinical data show great promise for TransCon CNP to be an effective and well-tolerated drug that provides sustained levels of CNP in a convenient once-weekly dose, while avoiding high systemic CNP bolus concentrations that can induce cardiovascular side effects.
A New Route to 2,7‐ and 7‐Functionalized Labdanes
A new route for the synthesis of 2,7- and 7-functionalized labdanes starts from (R)-carvone (1). 11-Nordrim-7-en-9-one (15) is an appropriate starting material for the total synthesis of hispanone
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