• Publications
  • Influence
Crystal Structure of a Photolyase Bound to a CPD-Like DNA Lesion After in Situ Repair
DNA photolyases use light energy to repair DNA that comprises ultraviolet-induced lesions such as the cis-syn cyclobutane pyrimidine dimers (CPDs). Here we report the crystal structure of a DNAExpand
  • 282
  • 14
Recognition and repair of UV lesions in loop structures of duplex DNA by DASH-type cryptochrome
DNA photolyases and cryptochromes (cry) form a family of flavoproteins that use light energy in the blue/UV-A region for the repair of UV-induced DNA lesions or for signaling, respectively. VeryExpand
  • 130
  • 10
  • PDF
CPD Damage Recognition by Transcribing RNA Polymerase II
Cells use transcription-coupled repair (TCR) to efficiently eliminate DNA lesions such as ultraviolet light–induced cyclobutane pyrimidine dimers (CPDs). Here we present the structure-based mechanismExpand
  • 155
  • 4
PqsBC, a Condensing Enzyme in the Biosynthesis of the Pseudomonas aeruginosa Quinolone Signal
Pseudomonas aeruginosa produces a number of alkylquinolone-type secondary metabolites best known for their antimicrobial effects and involvement in cell-cell communication. In the alkylquinoloneExpand
  • 37
  • 4
  • PDF
Natural and Non‐natural Antenna Chromophores in the DNA Photolyase from Thermus Thermophilus
X‐ray crystallographic and functional analysis of the class I DNA photolyase from Thermus thermophilus revealed the binding of flavin mononucleotide (FMN) as an antenna chromophore. The binding modeExpand
  • 47
  • 2
Characterization of a New Thermophilic Spore Photoproduct Lyase from Geobacillus stearothermophilus (SplG) with Defined Lesion Containing DNA Substrates*
The Geobacillus stearothermophilus splG gene encodes a thermophilic spore photoproduct lyase (SplG) that belongs to the family of radical S-adenosylmethionine (AdoMet) enzymes. The aerobicallyExpand
  • 37
  • 2
  • PDF
PqsL uses reduced flavin to produce 2-hydroxylaminobenzoylacetate, a preferred PqsBC substrate in alkyl quinolone biosynthesis in Pseudomonas aeruginosa
Alkyl hydroxyquinoline N-oxides (AQNOs) are antibiotic compounds produced by the opportunistic bacterial pathogen Pseudomonas aeruginosa. They are products of the alkyl quinolone (AQ) biosyntheticExpand
  • 13
  • 2
Crystal structure of the T(6-4)C lesion in complex with a (6-4) DNA photolyase and repair of UV-induced (6-4) and Dewar photolesions.
UV-light irradiation induces the formation of highly mutagenic lesions in DNA, such as cis-syn cyclobutane pyrimidine dimers (CPD photoproducts), pyrimidine(6-4)pyrimidone photoproducts ((6-4)Expand
  • 56
  • 1
New catalytic approaches towards the enantioselective halogenation of alkenes.
  • U. Hennecke
  • Medicine, Chemistry
  • Chemistry, an Asian journal
  • 5 March 2012
The addition of electrophilic reagents to the carbon-carbon double bond is one of the most fundamental reactions in organic chemistry. Halogen electrophiles constitute probably the most importantExpand
  • 150