• Publications
  • Influence
Local translation of RhoA regulates growth cone collapse
Neuronal development requires highly coordinated regulation of the cytoskeleton within the developing axon. This dynamic regulation manifests itself in axonal branching, turning and pathfinding,Expand
  • 394
  • 44
Intra-axonal translation and retrograde trafficking of CREB promotes neuronal survival
During development of the nervous system, axons and growth cones contain mRNAs such as β-actin, cofilin and RhoA, which are locally translated in response to guidance cues. Intra-axonal translationExpand
  • 256
  • 15
Axonal elongation triggered by stimulus-induced local translation of a polarity complex protein
During development, axon growth rates are precisely regulated to provide temporal control over pathfinding. The precise temporal regulation of axonal growth is a key step in the formation ofExpand
  • 140
  • 11
Functional and Selective RNA Interference in Developing Axons and Growth Cones
Developing axons and growth cones contain “local” mRNAs that are translated in response to various extracellular signaling molecules and have roles in several processes during axonal development,Expand
  • 160
  • 9
  • PDF
Axonally Synthesized ATF4 Transmits a Neurodegenerative Signal across Brain Regions
In Alzheimer's disease (AD) brain, exposure of axons to Aβ causes pathogenic changes that spread retrogradely by unknown mechanisms, affecting the entire neuron. We found that locally applied Aβ1-42Expand
  • 176
  • 5
  • PDF
Soluble adenylyl cyclase is required for netrin-1 signaling in nerve growth cones
Growth cones at the tips of nascent and regenerating axons direct axon elongation. Netrin-1, a secreted molecule that promotes axon outgrowth and regulates axon pathfinding, elevates cyclic AMPExpand
  • 96
  • 4
Function and translational regulation of mRNA in developing axons.
The capacity to synthesize proteins in axons is limited to early stages of neuronal development, while axons are undergoing elongation and pathfinding. Although the roles of local protein synthesisExpand
  • 69
  • 3
Regulation of Brain Proteolytic Activity Is Necessary for the In Vivo Function of NMDA Receptors
Serine proteases are considered to be involved in plasticity-related events in the nervous system, but their in vivo targets and the importance of their control by endogenous inhibitors are still notExpand
  • 47
  • 3
  • PDF
Local translation of TC10 is required for membrane expansion during axon outgrowth
The surface of developing axons expands in a process mediated by the exocyst complex. The spatial-temporal regulation of the exocyst is only partially understood. Here we report that stimulatedExpand
  • 32
  • 3
Coupled local translation and degradation regulate growth cone collapse
Local translation mediates axonal responses to Semaphorin3A (Sema3A) and other guidance cues. However, only a subset of the axonal proteome is locally synthesized, while most proteins are traffickedExpand
  • 29
  • 3